An implantable device for wireless monitoring of diverse physio-behavioral characteristics in freely behaving small animals and interacting groups.

Autor:	Ouyang W; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Kilner KJ; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA., Xavier RMP; NeuroLux Inc., Northfield, IL 60093, USA., Liu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Lu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Feller SM; NeuroLux Inc., Northfield, IL 60093, USA., Pitts KM; Department of Biological Structure, University of Washington, Seattle, WA 98195, USA., Wu M; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Ausra J; NeuroLux Inc., Northfield, IL 60093, USA., Jones I; NeuroLux Inc., Northfield, IL 60093, USA., Wu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Luan H; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Trueb J; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Higbee-Dempsey EM; Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA., Stepien I; Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA., Ghoreishi-Haack N; Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA., Haney CR; Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL 60208, USA., Li H; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA., Kozorovitskiy Y; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Heshmati M; Department of Biological Structure, University of Washington, Seattle, WA 98195, USA; Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA 98195, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA., Banks AR; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA., Golden SA; Department of Biological Structure, University of Washington, Seattle, WA 98195, USA; Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA 98195, USA. Electronic address: sagolden@uw.edu., Good CH; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA. Electronic address: cameron.good@northwestern.edu., Rogers JA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Chemistry, Northwestern University, Evanston, IL 60208, USA; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA. Electronic address: jrogers@northwestern.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2024 Jun 05; Vol. 112 (11), pp. 1764-1777.e5. Date of Electronic Publication: 2024 Mar 26.
DOI:	10.1016/j.neuron.2024.02.020
Abstrakt:	Comprehensive, continuous quantitative monitoring of intricately orchestrated physiological processes and behavioral states in living organisms can yield essential data for elucidating the function of neural circuits under healthy and diseased conditions, for defining the effects of potential drugs and treatments, and for tracking disease progression and recovery. Here, we report a wireless, battery-free implantable device and a set of associated algorithms that enable continuous, multiparametric physio-behavioral monitoring in freely behaving small animals and interacting groups. Through advanced analytics approaches applied to mechano-acoustic signals of diverse body processes, the device yields heart rate, respiratory rate, physical activity, temperature, and behavioral states. Demonstrations in pharmacological, locomotor, and acute and social stress tests and in optogenetic studies offer unique insights into the coordination of physio-behavioral characteristics associated with healthy and perturbed states. This technology has broad utility in neuroscience, physiology, behavior, and other areas that rely on studies of freely moving, small animal models. Competing Interests: Declaration of interests J.A.R. and A.R.B. are co-founders of a company, NeuroLux Inc., that has potential commercial interest in this technology. C.H.G., K.J.K., R.M.P.X., S.M.F., J.A., and I.J. are employees of NeuroLux Inc. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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