Tofogliflozin Delays Portal Hypertension and Hepatic Fibrosis by Inhibiting Sinusoidal Capillarization in Cirrhotic Rats.
Autor: | Asada S; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Kaji K; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Nishimura N; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Koizumi A; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Matsuda T; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Tanaka M; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Yorioka N; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Sato S; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Kitagawa K; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Namisaki T; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Akahane T; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan., Yoshiji H; Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Nara, Japan. |
---|---|
Jazyk: | angličtina |
Zdroj: | Cells [Cells] 2024 Mar 19; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 19. |
DOI: | 10.3390/cells13060538 |
Abstrakt: | Background: Liver cirrhosis leads to portal hypertension (PH) with capillarization of liver sinusoidal endothelial cells (LSECs), although drug treatment options for PH are currently limited. Sodium glucose transporter 2 inhibitors, which are antidiabetic agents, have been shown to improve endothelial dysfunction. We aimed to elucidate the effect of tofogliflozin on PH and liver fibrosis in a rat cirrhosis model. Methods: Male-F344/NSlc rats repeatedly received carbon tetrachloride (CCl Results: Tofogliflozin prevented PH with attenuated intrahepatic vasoconstriction, sinusoidal capillarization, and remodeling independent of glycemic status in CCl Conclusions: Our study provides strong support for tofogliflozin in the prevention of liver cirrhosis-related PH. |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |