The Natural History of Patients With Pre-Existing and De Novo Inflammatory Bowel Disease After Solid Organ Transplantation: EITOS Study of GETECCU.

Autor:	Bastón-Rey I; Gastroenterology Department, Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute, Santiago de Compostela, Spain., Rodríguez-Lago I; Gastroenterology Department, Hospital Universitario de Galdakao and Biocruces Bizkaia Health Research Institute, Galdakao, Spain., Luque AM; Gastroenterology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Caballol B; Gastroenterology Department, Hospital Clínic i Provincial, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain., Soutullo-Castiñeiras C; Gastroenterology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Bravo A; Gastroenterology Department, Hospital Regional Universitario de Málaga, Málaga, Spain., Castaño A; Gastroenterology Department, Hospital Universitario Central de Asturias, Oviedo, Spain., Gros B; Gastroenterology Department, Hospital Universitario Reina Sofía, IMIBIC, Universidad de Córdoba, Córdoba, Spain., Bernal L; Gastroenterology Department, Hospital General de Alicante and Instituto de Investigación Sanitaria y Biomédica de Alicante ISABIAL, Alicante, Spain., Diz-Lois MT; Gastroenterology Department, Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain., Alonso-Galán H; Gastroenterology Department, Hospital Universitario Donostia and Biodonostia Health Research Institute, San Sebastián- Gipuzkoa, Spain., Cañete F; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain., Castro B; Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain., Pérez-Galindo P; Gastroenterology Department, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., González-Muñoza C; Gastroenterology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain., El Hajra I; Gastroenterology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain., Martínez-Montiel P; Gastroenterology Department, Hospital Universitario 12 de Octubre, Madrid, Spain., Alonso-Abreu I; Gastroenterology Department, Hospital Universitario de Canarias, Tenerife, Spain., Mesonero F; Gastroenterology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain., González-Vivo M; Gastroenterology Department, Hospital del Mar, Barcelona, Spain., Peries L; Gastroenterology Department, Hospital Josep Trueta, Girona, Spain., Martín-Arranz E; Gastroenterology Department, Hospital Universitario La Paz, Madrid, Spain., Abril C; Gastroenterology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain., Marín-Jiménez I; Gastroenterology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Baltar R; Gastroenterology Department, Hospital Universitario de Álava, Vitoria, Spain., Vicuña M; Gastroenterology Department, Hospital Universitario de Navarra, Navarra, Spain., Moreno N; Gastroenterology Department, Hospital Doctor Peset, Valencia, Spain., Brunet E; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.; Gastroenterology Department, Hospital Universitari Parc Taulí, Sabadell, Spain., Rubín de Célix C; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.; Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa and Universidad Autónoma de Madrid, Madrid, Spain., Fajardo I; Gastroenterology Department, Hospital Universitari Mútua Terrasa, Barcelona, Spain., Cruz N; Gastroenterology Department, Lanzarote, Spain., Calvino-Suárez C; Gastroenterology Department, Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute, Santiago de Compostela, Spain., Rojas-Feria M; Gastroenterology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Fernández-Clotet A; Gastroenterology Department, Hospital Clínic i Provincial, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain., Gimeno-Torres M; Gastroenterology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Nieto-Garcia L; Gastroenterology Department, Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute, Santiago de Compostela, Spain., de la Iglesia D; Gastroenterology Department, Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute, Santiago de Compostela, Spain., Zabana Y; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.; Gastroenterology Department, Hospital Universitari Mútua Terrasa, Barcelona, Spain., Suárez-Ferrer C; Gastroenterology Department, Hospital Universitario La Paz, Madrid, Spain., Barreiro de Acosta M; Gastroenterology Department, Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute, Santiago de Compostela, Spain.
Jazyk:	angličtina
Zdroj:	Inflammatory bowel diseases [Inflamm Bowel Dis] 2024 Mar 22. Date of Electronic Publication: 2024 Mar 22.
DOI:	10.1093/ibd/izae041
Abstrakt:	Background: Limited data are available on the outcome of inflammatory bowel disease (IBD) in patients with solid organ transplantation (SOT). We describe the natural history of pre-existing IBD and de novo IBD after SOT. Methods: This was a retrospective, multicenter study that included patients with pre-existing IBD at the time of SOT and patients with de novo IBD after SOT. The primary outcome was IBD progression, defined by escalation of medical treatment, surgical therapy, or hospitalization due to refractory IBD. Risk factors were identified using multivariate Cox proportional hazard analysis. Results: A total of 177 patients (106 pre-existing IBD and 71 de novo IBD) were included. Most patients with pre-existing IBD (92.5%) were in remission before SOT. During follow-up, 32% of patients with pre-existing IBD had disease progression, with a median time between SOT and IBD progression of 2.2 (interquartile range, 1.3-4.6) years. In the de novo cohort, 55% of patients had disease progression with a median time to flare of 1.9 (interquartile range, 0.8-3.9) years after diagnosis. In the pre-existing IBD cohort, active IBD at the time of SOT (hazard ratio, 1.80; 95% confidence interval, 1.14-2.84; P = .012) and the presence of extraintestinal manifestations (hazard ratio, 3.10; 95% confidence interval, 1.47-6.54; P = .003) were predictive factors for IBD progression. Conclusions: One-third of patients with pre-existing IBD and about half of patients with de novo IBD have disease progression after SOT. Active IBD at the time of SOT and the presence of extraintestinal manifestations were identified as risk factors for IBD progression. (© The Author(s) 2024. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu