Impact of age and apolipoprotein E ε4 status on regional white matter hyperintensity volume and cognition in healthy aging.

Autor:	Van Etten EJ; Department of Psychology, University of Arizona, Tucson, AZ, USA.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Bharadwaj PK; Department of Psychology, University of Arizona, Tucson, AZ, USA.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Grilli MD; Department of Psychology, University of Arizona, Tucson, AZ, USA.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.; Department of Neurology, University of Arizona, Tucson, AZ, USA., Raichlen DA; Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Hishaw GA; Department of Neurology, University of Arizona, Tucson, AZ, USA., Huentelman MJ; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.; Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Trouard TP; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA., Alexander GE; Department of Psychology, University of Arizona, Tucson, AZ, USA.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Department of Psychiatry, University of Arizona, Tucson, AZ, USA.; Neuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.; Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2024 Jul; Vol. 30 (6), pp. 553-563. Date of Electronic Publication: 2024 Mar 22.
DOI:	10.1017/S1355617724000122
Abstrakt:	Objective: White matter hyperintensity (WMH) volume is a neuroimaging marker of lesion load related to small vessel disease that has been associated with cognitive aging and Alzheimer's disease (AD) risk. Method: The present study sought to examine whether regional WMH volume mediates the relationship between APOE ε4 status, a strong genetic risk factor for AD, and cognition and if this association is moderated by age group differences within a sample of 187 healthy older adults (APOE ε4 status [carrier/non-carrier] = 56/131). Results: After we controlled for sex, education, and vascular risk factors, ANCOVA analyses revealed significant age group by APOE ε4 status interactions for right parietal and left temporal WMH volumes. Within the young-old group (50-69 years), ε4 carriers had greater right parietal and left temporal WMH volumes than non-carriers. However, in the old-old group (70-89 years), right parietal and left temporal WMH volumes were comparable across APOE ε4 groups. Further, within ε4 non-carriers, old-old adults had greater right parietal and left temporal WMH volumes than young-old adults, but there were no significant differences across age groups in ε4 carriers. Follow-up moderated mediation analyses revealed that, in the young-old, but not the old-old group, there were significant indirect effects of ε4 status on memory and executive functions through left temporal WMH volume. Conclusions: These findings suggest that, among healthy young-old adults, increased left temporal WMH volume, in the context of the ε4 allele, may represent an early marker of cognitive aging with the potential to lead to greater risk for AD.
Databáze:	MEDLINE
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