Dermal Regeneration Template in the Management and Reconstruction of Burn Injuries and Complex Wounds: A Review.

Autor:	Gupta S; From Loma Linda University, Loma Linda, Calif., Moiemen N; University of Birmingham, Birmingham, UK., Fischer JP; University of Pennsylvania, Philadelphia, Pa., Attinger C; Georgetown University Hospital, Washington D.C., Jeschke MG; Hamilton Health Sciences, Hamilton, Ontario, Canada and McMaster University, Hamilton, Ontario, Canada., Taupin P; Integra LifeSciences Corporation, Princeton, N.J., Orgill DP; Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Jazyk:	angličtina
Zdroj:	Plastic and reconstructive surgery. Global open [Plast Reconstr Surg Glob Open] 2024 Mar 20; Vol. 12 (3), pp. e5674. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).
DOI:	10.1097/GOX.0000000000005674
Abstrakt:	Background: Dermal scaffolds have created a paradigm shift for burn and wound management by providing improved healing and less scarring, while improving cosmesis and functionality. Dermal regeneration template (DRT) is a bilayer membrane for dermal regeneration developed by Yannas and Burke in the 1980s. The aim of this review is to summarize clinical evidence for dermal scaffolds focusing on DRT for the management and reconstruction of burn injuries and complex wounds. Methods: A comprehensive search of PubMed was performed from the start of indexing through November 2022. Articles reporting on DRT use in patients with burns, limb salvage, and wound reconstruction were included with focus on high-level clinical evidence. Results: DRT has become an established alternative option for the treatment of full-thickness and deep partial-thickness burns, with improved outcomes in areas where cosmesis and functionality are important. In the management of diabetic foot ulcers, use of DRT is associated with high rates of complete wound healing with a low risk of adverse outcomes. DRT has been successfully used in traumatic and surgical wounds, showing particular benefit in deep wounds and in the reconstruction of numerous anatomical sites. Conclusions: Considerable clinical experience has accrued with the use of DRT beyond its original application for thermal injury. A growing body of evidence from clinical studies reports the successful use of DRT to improve clinical outcomes and quality of life across clinical indications at a number of anatomical sites. Competing Interests: SG is former consultant for Integra LifeSciences Corporation. NM is former consultant for Integra LifeSciences Corporation (≥5 years ago). JPF received research funding from the National Institutes of Health, and is consultant for 3M, AbbVie, Becton Dickinson, Baxter, Integra LifeSciences Corporation, and Gore. CEA is former consultant for Integra LifeSciences Corporation (≥5 years ago). MGJ received research funding and consulting fees from Integra LifeSciences Corporation. PT is an employee of Integra LifeSciences Corporation and owns common stock of Integra LifeSciences Holdings Corporation, its parent corporation. DPO received research funding and consulting fees from Integra LifeSciences Corporation. (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)
Databáze:	MEDLINE
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