The association of infant and mother gut microbiomes with development of allergic diseases in children: a systematic review.

Autor:	Mousavian AH; Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Zare Garizi F; Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran., Ghoreshi B; Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Ketabi S; Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Eslami S; Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran., Ejtahed HS; Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Qorbani M; Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Jazyk:	angličtina
Zdroj:	The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2024 Oct; Vol. 61 (10), pp. 1121-1135. Date of Electronic Publication: 2024 Apr 04.
DOI:	10.1080/02770903.2024.2332921
Abstrakt:	Objective: It is believed that gut microbiota alteration leads to both intestinal and non-intestinal diseases in children. Since infants inherit maternal microbiota during pregnancy and lactation, recent studies suggest that changes in maternal microbiota can cause immune disorders as well. This systematic review was designed to assess the association between the child and mother's gut microbiome and allergy development in childhood. Data Sources: In this systematic review, international databases including PubMed, Scopus, and ISI/WOS were searched until January 2023 to identify relevant studies. Study Selections: Observational studies that analyzed infant or maternal stool microbiome and their association with allergy development in children were included in this study. Data extraction and quality assessment of the included studies were independently conducted by two researchers. Results: Of the 1694 papers evaluated, 21 studies examined neonate gut microbiome by analyzing stool samples and six studies examined maternal gut microbiota. A total of 5319 participants were included in this study. Asthma followed by eczema and dermatitis were the most common allergy disorders among children. Urbanization caused a lack of diversity in the bacterial microbiota as well as lower levels of Bifidobacterium and Lachnospira associated with a higher risk of allergy. In contrast, higher levels of Roseburia and Flavonifractor were associated with lower allergy risk. Conclusions: This systematic review shows that gut microbiota may be associated with allergy development. Further studies are required to provide a definitive answer.
Databáze:	MEDLINE
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