Mindfulness-based cognitive therapy neurobiology in treatment-resistant obsessive-compulsive disorder: A domain-related resting-state networks approach.

Autor: De la Peña-Arteaga V; Sant Pau Mental Health Research Group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain., Cano M; Sant Pau Mental Health Research Group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Porta-Casteràs D; Sant Pau Mental Health Research Group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain; Mental Health Department, Unitat de Neurociència Traslacional, Parc Taulí University Hospital, Institut d'Investigació i Innovació Sanitària Parc Taulí (I3PT), Sabadell, Spain; Department of Psychiatry and Forensic Medicine, School of Medicine Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain., Vicent-Gil M; Sant Pau Mental Health Research Group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Miquel-Giner N; Mental Health Department, Unitat de Neurociència Traslacional, Parc Taulí University Hospital, Institut d'Investigació i Innovació Sanitària Parc Taulí (I3PT), Sabadell, Spain; Department of Mental Health, Parc Sanitari Sant Joan de Déu, Cornellà de Llobregat, Spain., Martínez-Zalacaín I; Department of Radiology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain; Psychiatry and Mental Health Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain., Mar-Barrutia L; Psychiatry and Mental Health Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain., López-Solà M; Department of Medicine, School of Medicine and Health Sciences, Universitat de Barcelona - UB, Barcelona, Spain., Andrews-Hanna JR; Department of Psychology - Cognitive Science, University of Arizona, Tucson, United States of America., Soriano-Mas C; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Psychiatry and Mental Health Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Social Psychology and Quantitative Psychology, Universitat de Barcelona - UB, Barcelona, Spain., Alonso P; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Psychiatry and Mental Health Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Clinical Sciences, School of Medicine, Universitat de Barcelona - UB, L'Hospitalet de Llobregat, Spain., Serra-Blasco M; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; ICOnnecta't e-Health Program of the Institut Català d'Oncologia (ICO), L'Hospitalet de Llobregat, Spain; Psycho-oncology and Digital Health Group, Health Services Research in Cancer, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet del Llobregat, Spain. Electronic address: mariaserrab@iconcologia.net., López-Solà C; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Mental Health Department, Unitat de Neurociència Traslacional, Parc Taulí University Hospital, Institut d'Investigació i Innovació Sanitària Parc Taulí (I3PT), Sabadell, Spain; Health Clinical Psychology Section, Department of Psychiatry & Clinical Psychology, Institut Clínic de Neurociències (ICN), Hospital Clínic, Barcelona, Spain. Electronic address: clalopez@clinic.cat., Cardoner N; Sant Pau Mental Health Research Group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain; Network Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Jazyk: angličtina
Zdroj: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2024 May; Vol. 82, pp. 72-81. Date of Electronic Publication: 2024 Mar 18.
DOI: 10.1016/j.euroneuro.2024.02.011
Abstrakt: Mindfulness-based cognitive therapy (MBCT) stands out as a promising augmentation psychological therapy for patients with obsessive-compulsive disorder (OCD). To identify potential predictive and response biomarkers, this study examines the relationship between clinical domains and resting-state network connectivity in OCD patients undergoing a 3-month MBCT programme. Twelve OCD patients underwent two resting-state functional magnetic resonance imaging sessions at baseline and after the MBCT programme. We assessed four clinical domains: positive affect, negative affect, anxiety sensitivity, and rumination. Independent component analysis characterised resting-state networks (RSNs), and multiple regression analyses evaluated brain-clinical associations. At baseline, distinct network connectivity patterns were found for each clinical domain: parietal-subcortical, lateral prefrontal, medial prefrontal, and frontal-occipital. Predictive and response biomarkers revealed significant brain-clinical associations within two main RSNs: the ventral default mode network (vDMN) and the frontostriatal network (FSN). Key brain nodes -the precuneus and the frontopolar cortex- were identified within these networks. MBCT may modulate vDMN and FSN connectivity in OCD patients, possibly reducing symptoms across clinical domains. Each clinical domain had a unique baseline brain connectivity pattern, suggesting potential symptom-based biomarkers. Using these RSNs as predictors could enable personalised treatments and the identification of patients who would benefit most from MBCT.
Competing Interests: Declaration of competing interest Over the past five years, Narcís Cardoner has received research grants and/or honorary fees as a consultant or speaker from various organizations, including Adamed, Angelini, Content Ed Net Communications, Elsevier, Esteve, Exeltis, Janssen, Lundbeck, Pfizer, Servier, Viatris, Fundació la Caixa, Carlos III Health Institute, ERA-NET Neuron, the Spanish Ministry of Science and Innovation (CIBERSAM), and Health Research and Innovation Strategic Plan (PERIS) 2016–2020, Marató TV3. Additionally, Pino Alonso has collaborated with Biohaven, Boston Scientific, Medtronic, and has received funding from Carlos III Health Institute and Marató TV3. All other authors declare that they have no conflicts of interest.
(Copyright © 2024 Elsevier B.V. and ECNP. All rights reserved.)
Databáze: MEDLINE
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