A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.

Autor:	Nagarajan P; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Miller CL; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesvil le, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville ,VA, USA., Kraja AT; University of Mississippi Medical Center, Jackson, MS, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Lee S; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Wang W; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Brown MR; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Morrison JL; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Giri A; Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., de las Fuentes L; Cardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, MO, USA.; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Gudmundsdottir V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Harris SE; Department of Psychology, The University of Edinburgh, Edinburgh, UK., Huang Z; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Kals M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Kho M; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Lefevre C; Department of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland., Mangino M; Department of Twin Research, King's College London, London, UK.; National Heart & Lung Institute, Cardiovascular Genomics and Precision Medicine, Imperial College London, London, UK., Milaneschi Y; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.; GGZ inGeest, Amsterdam, Netherlands., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Rao V; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Shen B; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Stadler S; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Sun Q; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tang J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Thériault S; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Qc, Canada., van der Graaf A; Statistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Wang Y; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Westerman KE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Yang Q; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Yasuharu T; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhu W; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Altschul D; Department of Psychology, The University of Edinburgh, Edinburgh, UK., Ansari MAY; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Anugu P; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Argoty-Pantoja AD; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Arzt M; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Aschard H; Department of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris, France.; Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, USA., Attia JR; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Bazzanno L; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Breyer MA; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Chen HH; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chen Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., de Vries PS; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Dimitrov LM; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Do A; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Du J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dupont CT; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Edwards TL; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US A., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Faquih T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Felix SB; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, Un iversity Medicine Greifswald, Greifswald, Germany., Fisher-Hoch SP; School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Graff M; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gu C; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Gu D; Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science an d Technology, Shenzhen, China., Hairston KG; Department of Endocrinology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Hanley AJ; Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Kuopio., Highland HM; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hood MM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kähönen M; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Karvonen-Gutierrez CA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kazuya S; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Kelly TN; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, USA., Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Framingham Heart Study, Framingham, MA, USA., Lin HJ; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Liu PY; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., McCormick JB; School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA., Mei H; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Meigs JB; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Menni C; Department of Twin Research, King's College London, London, UK., Nam K; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Pacheco NL; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Petty LE; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Polikowsky HG; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, and Department of Clinical Physiology and Nuclear Medicine, University of Turku, and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Riha RL; Department of Sleep Medicine, The University of Edinburgh, Edinburgh, UK., Risch L; Faculty of Medical Sciences , Institute for Laboratory Medicine, Private University in the Principality of Liecht enstein, Vaduz, Liechtenstein.; Center of Laboratory Medicine, Institute of Clinical Chemistry, University of Bern and Inselspital, Bern, Switze rland., Risch M; Central Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland.; Medical Laboratory, Dr. Risch Anstalt, Vaduz, Liechtenstein., Ruiz-Narvaez EA; Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA., Scott RJ; School of Biomedical Sciences and Pharmacy, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Sofer T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Völker U; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Wang G; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden, Netherlands., Wilson OD; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Xia R; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young KL; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhang R; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Below JE; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany.; KfH Kidney Centre Traunstein, Traunstein, Germany., Conen D; Population Health Research Institute, Medicine, McMaster University, Hamilton, On, Canada., Cox SR; Department of Psychology, The University of Edinburgh, Edinburgh, UK., Dörr M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, Un iversity Medicine Greifswald, Greifswald, Germany., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Fox ER; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Franceschini N; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gharib SA; Pulmonary, Critical Care and Sleep Medicine, Medicine, University of Washington, Seattle, WA, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland., Harlow SD; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.; Tulane University Translational Sciences Institute, New Orleans, LA , USA., Holliday EG; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Kutalik Z; Statistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Kuopio.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Lee S; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland., Li C; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Morrison AC; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Penninx BW; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.; GGZ inGeest, Amsterdam, Netherlands., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Spector TD; Department of Twin Research, King's College London, London, UK., Wagenknecht LE; Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., North KE; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Hung AM; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Manning AK; Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gauderman J; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Chen H; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA., Munroe PB; Clinical Pharmacology and Precision Medicine, Queen Mary University of London, London, UK., Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Lei den, Netherlands., Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Lei den, Netherlands., Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 08. Date of Electronic Publication: 2024 Mar 08.
DOI:	10.1101/2024.03.07.24303870
Abstrakt:	Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausibility of distinct influences of both sleep duration extremes in cardiovascular health. With several of our loci reflecting specificity towards population background or sex, our discovery sheds light on the importance of embracing granularity when addressing heterogeneity entangled in gene-environment interactions, and in therapeutic design approaches for blood pressure management. Competing Interests: Conflict of Interest/Disclosures: C.L.M. has received funding from AstraZeneca not related to the current study. B.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. D.C. receives consultancy fees from Roche Diagnostics and Trimedics and speaker fees from Servier. D.A.L. has received support from Medtronic LTD and Roche Diagnostics for biomarker research not related to the current study. The remaining authors declare no competing interests.
Databáze:	MEDLINE
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