| Autor: |
Guo H; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. zhaiqixiao@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China., He X; Rehabilitation Hospital of Huishan District, Wuxi, Jiangsu 214181, China., Yu L; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. zhaiqixiao@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China., Tian F; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. zhaiqixiao@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China., Chen W; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. zhaiqixiao@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China., Zhai Q; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. zhaiqixiao@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. |
| Abstrakt: |
Antibiotic-associated diarrhea (AAD) is a self-limiting condition that can occur during antibiotic therapy. Our previous studies have found that a combination of Bacteroides uniformis and Bifidobacterium adolescentis can effectively alleviate AAD. However, the use of B. uniformis is still strictly limited. Therefore, this study attempted to use yeast β-glucan to enrich the abundance of B. uniformis in the intestine and supplement Bifidobacterium adolescentis to exert a synergistic effect. The lincomycin hydrochloride-induced AAD model was administered yeast β-glucan or a mixture of B. adolescentis CCFM1285 by gavage for one week. Subsequently, changes in the colonic histopathological structure, inflammatory factors, intestinal epithelial permeability and integrity, metabolites, and gut microbiota diversity were assessed. We found that yeast β-glucan, alone or in combination with B. adolescentis CCFM1285, can help attenuate systemic inflammation, increase the rate of tissue structural recovery, regulate metabolism, and restore the gut microbiota. Specifically, the combination of yeast β-glucan and B. adolescentis CCFM1285 was more effective in decreasing interleukin-6 levels, improving pathological changes in the colon, and upregulating occludin expression. Therefore, our study showed that the combination of yeast β-glucan and B. adolescentis CCFM1285 is an efficacious treatment for AAD. |
