Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue.

Autor:	Lennartz M; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Amezada D; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Höflmayer D; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Dwertmann Rico S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., von Bargen C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Kind S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Reiswich V; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Viehweger F; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Lutz F; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Bertram V; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Fraune C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Gorbokon N; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Weidemann S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Hube-Magg C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Menz A; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Uhlig R; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Krech T; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer).; the Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany (Krech, Lebok)., Hinsch A; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Burandt E; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Sauter G; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Simon R; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Kluth M; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Marx AH; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer).; the Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany (Marx)., Lebok P; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer).; the Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany (Krech, Lebok)., Dum D; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Minner S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Jacobsen F; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Clauditz TS; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Bernreuther C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer)., Steurer S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok, Dum, Minner, Jacobsen, Clauditz, Bernreuther, Steurer).
Jazyk:	angličtina
Zdroj:	Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2024 Mar 15. Date of Electronic Publication: 2024 Mar 15.
DOI:	10.5858/arpa.2023-0281-OA
Abstrakt:	Context.—: Steroidogenic acute regulatory (StAR) protein is a mitochondrial transport protein with a critical regulatory role for steroid hormone production. The tissue distribution of StAR expression is limited to few human normal tissues. Objective.—: To assess the diagnostic and prognostic value of StAR immunohistochemistry analysis. Design.—: A tissue microarray containing 19 202 samples from 152 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Result.—: StAR immunostaining occurred in 198 (1.2%) of the 17 135 analyzable tumors. StAR expression was observed in 27 of 152 tumor categories, 9 of which included at least 1 strongly positive case. The highest rate of StAR positivity occurred in Leydig cell tumors of the testis and the ovary (100%), steroid cell tumors of the ovary (100%), adrenocortical carcinomas (93%) and adenomas (87%), Sertoli-Leydig cell tumors (67%) and granulosa cell tumors of the ovary (56%), as well as seminomas (7%). Nineteen other tumor entities showed-a usually weak-StAR positivity in less than 6% of cases. A comparison with preexisting Melan-A (a melanocyte antigen) data revealed that StAR was more often positive in adrenocortical neoplasms and in Leydig cell tumors while StAR (but not Melan-A) was negative in Sertoli cell tumors. Conclusions.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue. (© 2024 College of American Pathologists.)
Databáze:	MEDLINE
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