Reusable graphite-based electrochemical sensors for L-dopa and dopamine detection.

Autor: Blasques RV; Laboratory of Sensors, Nanomedicine and Nanostructured Materials, Federal University of São Carlos, Araras, 13600-970, Brazil.; Department of Physics, Chemistry, and Mathematics, Federal University of São Carlos, São Paulo, Sorocaba, 18052-780, Brazil., Stefano JS; Laboratory of Sensors, Nanomedicine and Nanostructured Materials, Federal University of São Carlos, Araras, 13600-970, Brazil., da Silva VAOP; Laboratory of Sensors, Nanomedicine and Nanostructured Materials, Federal University of São Carlos, Araras, 13600-970, Brazil., Brazaca LC; Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brazil. lais.brazaca@usp.br., Janegitz BC; Laboratory of Sensors, Nanomedicine and Nanostructured Materials, Federal University of São Carlos, Araras, 13600-970, Brazil. brunocj@ufscar.br.
Jazyk: angličtina
Zdroj: Mikrochimica acta [Mikrochim Acta] 2024 Mar 14; Vol. 191 (4), pp. 197. Date of Electronic Publication: 2024 Mar 14.
DOI: 10.1007/s00604-024-06271-x
Abstrakt: A fully reusable electrochemical device is proposed for the first time made from laser cutting and a homemade conductive ink composed of carbon and nail polish. As a sensor substrate, we applied polymethyl methacrylate, which allows the surface to be renewed by simply removing and reapplying a new layer of ink. In addition to the ease of renewing the sensor's conductive surface, the design of the device has allowed for the integration of different forms of analysis. The determination of L-Dopa was performed using DPV, which presented a linear response range between 5.0 and 1000.0 μmol L -1 , and a LOD of 0.11 μmol L -1 . For dopamine, a flow injection analysis system was employed, and using the amperometric technique measurements were performed with a linear ranging from 2.0 to 100.0 μmol L -1  and a LOD of 0.26 μmol L -1 . To demonstrate its applicability, the device was used in the quantification of analytes in pharmaceutical drug and synthetic urine samples.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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