Biomarkers for urinary tract infection: present and future perspectives.

Autor: Mattoo TK; Pediatric Nephrologist, Wayne Pediatrics, Detroit, MI, USA. Tmattoo@med.wayne.edu.; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. Tmattoo@med.wayne.edu.; Department of Urology, Wayne State University School of Medicine, Detroit, MI, USA. Tmattoo@med.wayne.edu., Spencer JD; The Kidney and Urinary Tract Center, Nationwide Children's Abigail Wexner Research Institute, Columbus, OH, USA.; The Ohio State University College of Medicine, Columbus, OH, USA.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Oct; Vol. 39 (10), pp. 2833-2844. Date of Electronic Publication: 2024 Mar 14.
DOI: 10.1007/s00467-024-06321-9
Abstrakt: A prompt diagnosis of urinary tract infection (UTI) is necessary to minimize its symptoms and limit sequelae. The current UTI screening by urine test strip analysis and microscopic examination has suboptimal diagnostic accuracy. A definitive diagnosis of UTI by urine culture takes two to three days for the results. These limitations necessitate a need for better biomarkers for the diagnosis and subsequent management of UTI in children. Here, we review the value of currently available UTI biomarkers and highlight the potential of emerging biomarkers that can facilitate a more rapid and accurate UTI diagnosis. Of the newer UTI biomarkers, the most promising are blood procalcitonin (PCT) and urinary neutrophil gelatinase-associated lipocalin (NGAL). PCT can provide diagnostic benefits and should be considered in patients who have a blood test for other reasons. NGAL, which is on the threshold of clinical care, needs more research to address its scope and utilization, including point-of-care application. Employment of these and other biomarkers may ultimately improve UTI diagnosis, guide UTI therapy, reduce antibiotic use, and mitigate UTI complications.
(© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
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