SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis.

Autor:	Baxter RM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Cabrera-Martinez B; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Ghosh T; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO., Rester C; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Moreno MG; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Borko TL; Department of Neurology, Sections of Neuroimmunology, Neuroinfectious Disease, and Neurohospitalist, University of Colorado School of Medicine, Aurora, CO., Selva S; Department of Neurology, Sections of Neuroimmunology, Neuroinfectious Disease, and Neurohospitalist, University of Colorado School of Medicine, Aurora, CO., Fleischer CL; Department of Medicine, Division of Rheumatology, University of Colorado, School of Medicine, Aurora, CO., Haakonsen N; Department of Medicine, Division of Infectious Diseases, University of Colorado, School of Medicine, Aurora, CO., Mayher A; Allergy and Immunology Research, Research Institute, Children's Hospital Colorado, Aurora, CO., Bowhay E; Allergy and Immunology Research, Research Institute, Children's Hospital Colorado, Aurora, CO., Evans C; Allergy and Immunology Research, Research Institute, Children's Hospital Colorado, Aurora, CO., Miller TM; Analytics Resource Center, Children's Hospital Colorado, Aurora, CO., Huey L; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado, School of Medicine, Aurora, CO., McWilliams J; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., van Bokhoven A; Department of Pathology, Section of Pathology Shared Resource, University of Colorado, Aurora, CO., Deane KD; Department of Medicine, Division of Rheumatology, University of Colorado, School of Medicine, Aurora, CO., Knight V; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado, School of Medicine, Aurora, CO., Jordan KR; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Ghosh D; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO., Klarquist J; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Kedl RM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO., Piquet AL; Department of Neurology, Sections of Neuroimmunology, Neuroinfectious Disease, and Neurohospitalist, University of Colorado School of Medicine, Aurora, CO., Hsieh EWY; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado, School of Medicine, Aurora, CO.
Jazyk:	angličtina
Zdroj:	ImmunoHorizons [Immunohorizons] 2024 Mar 01; Vol. 8 (3), pp. 254-268.
DOI:	10.4049/immunohorizons.2300108
Abstrakt:	The impact of B cell deficiency on the humoral and cellular responses to SARS-CoV2 mRNA vaccination remains a challenging and significant clinical management question. We evaluated vaccine-elicited serological and cellular responses in 1) healthy individuals who were pre-exposed to SARS-CoV-2 (n = 21), 2) healthy individuals who received a homologous booster (mRNA, n = 19; or Novavax, n = 19), and 3) persons with multiple sclerosis on B cell depletion therapy (MS-αCD20) receiving mRNA homologous boosting (n = 36). Pre-exposure increased humoral and CD4 T cellular responses in immunocompetent individuals. Novavax homologous boosting induced a significantly more robust serological response than mRNA boosting. MS-α CD20 had an intact IgA mucosal response and an enhanced CD8 T cell response to mRNA boosting compared with immunocompetent individuals. This enhanced cellular response was characterized by the expansion of only effector, not memory, T cells. The enhancement of CD8 T cells in the setting of B cell depletion suggests a regulatory mechanism between B and CD8 T cell vaccine responses. (Copyright © 2024 The Authors.)
Databáze:	MEDLINE
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