A neural m 6 A pathway regulates behavioral aggregation in migratory locusts.

Autor: Huang X; School of Life Science, Institutes of Life Science and Green Development, Hebei University, Baoding, 071002, China., Li Q; College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China., Xu Y; Institute of Health Sciences, Anhui University, Hefei, 230601, China., Li A; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China., Wang S; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China., Chen Y; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China., Zhang C; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China., Zhang X; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China., Wang H; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100101, China., Lv C; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100101, China., Sun B; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China., Li S; College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Kang L; School of Life Science, Institutes of Life Science and Green Development, Hebei University, Baoding, 071002, China. lkang@ioz.ac.cn.; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. lkang@ioz.ac.cn., Chen B; School of Life Science, Institutes of Life Science and Green Development, Hebei University, Baoding, 071002, China. chenbing@hbu.edu.cn.
Jazyk: angličtina
Zdroj: Science China. Life sciences [Sci China Life Sci] 2024 Jun; Vol. 67 (6), pp. 1242-1254. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1007/s11427-023-2476-1
Abstrakt: RNA N 6 -methyladenosine (m 6 A), as the most abundant modification of messenger RNA, can modulate insect behaviors, but its specific roles in aggregation behaviors remain unexplored. Here, we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta migratoria. Our results demonstrated that METTL3, METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or isolation. The individual knockdown of methyltransferases (i.e., METTL3 and METTL14) promoted locust movement and conspecific attraction, whereas ALKBH5 knockdown induced a behavioral shift toward the solitary phase. Furthermore, global transcriptome profiles revealed that m 6 A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of locusts. In summary, our in vivo characterization of the m 6 A functions in migratory locusts clearly demonstrated the crucial roles of the m 6 A pathway in effectively modulating aggregation behaviors.
(© 2023. Science China Press.)
Databáze: MEDLINE
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