Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults-the bone microarchitecture international consortium prospective cohort study.

Autor: Szulc P; INSERM UMR1033, University of Lyon, Lyon 69100, France., Dufour AB; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, United States.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States., Hannan MT; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, United States.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States., Kiel DP; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, United States.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States., Chapurlat R; INSERM UMR1033, University of Lyon, Lyon 69100, France., Sornay-Rendu E; INSERM UMR1033, University of Lyon, Lyon 69100, France., Merle B; INSERM UMR1033, University of Lyon, Lyon 69100, France., Boyd SK; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary AB, T2N 1N4, Canada., Whittier DE; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary AB, T2N 1N4, Canada., Hanley DA; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary AB, T2N 1N4, Canada., Goltzman D; Departments of Medicine, McGill University and McGill University Health Centre, Montreal, QC, H3A 0G4, Canada., Wong AKO; Joint Department of Medical Imaging, University Health Network; and Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5R 0A3, Canada., Lespessailles E; Department of Rheumatology and PRIMMO, University Hospital of Orléans, Orléans, 45234, France., Khosla S; Division of Endocrinology and Kogod Center on Aging, Mayo Clinic, Rochester, MN 55902, United States., Ferrari S; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, CH-1211, Switzerland., Biver E; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, CH-1211, Switzerland., Bouxsein ML; Dept of Orthopedic Surgery, Harvard Medical School, Center for Advanced Orthopaedics Studies, BIDMC, Boston, MA 02215, United States., Samelson EJ; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, United States.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
Jazyk: angličtina
Zdroj: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2024 May 24; Vol. 39 (5), pp. 561-570.
DOI: 10.1093/jbmr/zjae033
Abstrakt: Fracture risk increases with lower areal bone mineral density (aBMD); however, aBMD-related estimate of risk may decrease with age. This may depend on technical limitations of 2-dimensional (2D) dual energy X-ray absorptiometry (DXA) which are reduced with 3D high-resolution peripheral quantitative computed tomography (HR-pQCT). Our aim was to examine whether the predictive utility of HR-pQCT measures with fracture varies with age. We analyzed associations of HR-pQCT measures at the distal radius and distal tibia with two outcomes: incident fractures and major osteoporotic fractures. We censored follow-up time at first fracture, death, last contact or 8 years after baseline. We estimated hazard ratios (HR) and 95%CI for the association between bone traits and fracture incidence across age quintiles. Among 6835 men and women (ages 40-96) with at least one valid baseline HR-pQCT scan who were followed prospectively for a median of 48.3 months, 681 sustained fractures. After adjustment for confounders, bone parameters at both the radius and tibia were associated with higher fracture risk. The estimated HRs for fracture did not vary significantly across age quintiles for any HR-pQCT parameter measured at either the radius or tibia. In this large cohort, the homogeneity of the associations between the HR-pQCT measures and fracture risk across age groups persisted for all fractures and for major osteoporotic fractures. The patterns were similar regardless of the HR-pQCT measure, the type of fracture, or the statistical models. The stability of the associations between HR-pQCT measures and fracture over a broad age range shows that bone deficits or low volumetric density remain major determinants of fracture risk regardless of age group. The lower risk for fractures across measures of aBMD in older adults in other studies may be related to factors which interfere with DXA but not with HR-pQCT measures.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze: MEDLINE
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