Ultrarapid Iron Polymaltose Infusions Are Safe for Management of Iron Deficiency.

Autor:	Banakh I; Emergency Department Pharmacy Team leader, Pharmacy Department, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia., Turek M; Senior Pharmacist, Mental Health, Pharmacy Department, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia., Niewodowski D; General Medicine Hospital Medical Officer, Department of Medicine, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia., Sriamareswaran RK; Cardiology Registrar, Department of Medicine, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia., Yeaman F; Gastroenterology Advanced Trainee, Department of Medicine, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia., Vo L; Clinical Pharmacist, Pharmacy Department, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia., Churchill T; General Medicine Registrar, Department of Medicine, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	GE Portuguese journal of gastroenterology [GE Port J Gastroenterol] 2023 Jan 19; Vol. 31 (1), pp. 24-32. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2024).
DOI:	10.1159/000527794
Abstrakt:	Introduction: Iron deficiency is a common condition, especially among patients with kidney and heart failure and inflammatory bowel disease. Intravenous iron is the preferred method of treatment in these patients, but it usually requires prolonged iron polymaltose infusions or multiple administrations of alternative preparations. The aim of the study was to confirm the safety and patient acceptance of ultrarapid iron polymaltose infusions as an alternative to slower treatments and ferric carboxymaltose. Method: An open-label, phase 4 safety study was conducted at a tertiary hospital, with consenting participants diagnosed with iron deficiency and requiring iron polymaltose up to 1,500 mg receiving the infusion over 15 min. The acute adverse event (AE) rates and their severities were compared to historical controls of 1- and 4-h iron polymaltose infusions from a retrospective study of 648 patients from the same study site. Delayed AEs as well as participant infusion acceptability were also studied. Results: Three hundred participants over a 2-year period received ultrarapid infusions of iron polymaltose with an acute AE rate of 18.7% and severe AE rate of 1.0%. The total and mild infusion AE rates were higher compared to those of slower infusions ( p < 0.001), but comparable for moderate and severe AEs. Delayed reactions occurred in 12.5% of participants, with over 95% of them preferring repeat ultrarapid infusions if required again. Conclusion: Iron polymaltose can be safely infused at ultrarapid rates when compared to slower infusions, with similar safety to ferric carboxymaltose, offering greater convenience for patients and reduced healthcare costs. Competing Interests: The authors have no conflicts of interest to declare. Iouri Banakh has previously received a research grant from the Society of Hospital Pharmacists of Australia for an unrelated study and conference attendance support from DBL. (Copyright © 2023 by The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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