Redox mechanisms of environmental toxicants on male reproductive function.

Autor:	Hussain T; College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.; Animal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad, Pakistan., Metwally E; Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., Murtaza G; Department of Livestock and Fisheries, Government of Sindh, Karachi, Pakistan., Kalhoro DH; Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh, Pakistan., Chughtai MI; Animal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad, Pakistan., Tan B; College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China., Omur AD; Department of Artificial Insemination, Faculty, Veterinary Medicine, Ataturk University, Erzurum, Türkiye., Tunio SA; Department of Livestock Management, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh, Pakistan., Akbar MS; Faculty of Animal Husbandry and Veterinary Sciences, University of Poonch, Rawalakot, Pakistan., Kalhoro MS; Department of Agro-Industrial, Food, and Environmental Technology, Faculty of Applied Science, Food and Agro-Industrial Research Centre, King Mongkut's University of Technology North Bangkok, Bangkok, Thailand.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Feb 26; Vol. 12, pp. 1333845. Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024).
DOI:	10.3389/fcell.2024.1333845
Abstrakt:	Humans and wildlife, including domesticated animals, are exposed to a myriad of environmental contaminants that are derived from various human activities, including agricultural, household, cosmetic, pharmaceutical, and industrial products. Excessive exposure to pesticides, heavy metals, and phthalates consequently causes the overproduction of reactive oxygen species. The equilibrium between reactive oxygen species and the antioxidant system is preserved to maintain cellular redox homeostasis. Mitochondria play a key role in cellular function and cell survival. Mitochondria are vulnerable to damage that can be provoked by environmental exposures. Once the mitochondrial metabolism is damaged, it interferes with energy metabolism and eventually causes the overproduction of free radicals. Furthermore, it also perceives inflammation signals to generate an inflammatory response, which is involved in pathophysiological mechanisms. A depleted antioxidant system provokes oxidative stress that triggers inflammation and regulates epigenetic function and apoptotic events. Apart from that, these chemicals influence steroidogenesis, deteriorate sperm quality, and damage male reproductive organs. It is strongly believed that redox signaling molecules are the key regulators that mediate reproductive toxicity. This review article aims to spotlight the redox toxicology of environmental chemicals on male reproduction function and its fertility prognosis. Furthermore, we shed light on the influence of redox signaling and metabolism in modulating the response of environmental toxins to reproductive function. Additionally, we emphasize the supporting evidence from diverse cellular and animal studies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hussain, Metwally, Murtaza, Kalhoro, Chughtai, Tan, Omur, Tunio, Akbar and Kalhoro.)
Databáze:	MEDLINE
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