Genomic Imprinting and Random Monoallelic Expression.

Autor: Lobanova YV; Federal Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russia.; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia., Zhenilo SV; Federal Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russia. szhenilo@gmail.com.
Jazyk: angličtina
Zdroj: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2024 Jan; Vol. 89 (1), pp. 84-96.
DOI: 10.1134/S000629792401005X
Abstrakt: The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.
Databáze: MEDLINE