t(2;2;21;8)(p21;q37;q22;q22), a novel four-way complex translocation involving variant t(8;21) in case of acute myeloid leukemia : A case report and literature review.

Autor: Han B; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China., Jing Y; Department of Haematology, The Fifth Medical centre of Chinese PLA General Hospital, Beijing, China., Bi X; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China., Lin Y; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China., Li H; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China., Li H; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China., Ru K; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China; Department of Pathology and Lab Medicine, Shandong Cancer Hospital, Jinan, Shandong, China., Yang S; Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-aided Hematopathology Diagnosis, 5 Xinghua No.3 branch road, Tianjin, China. Electronic address: hbyangshaobin@163.com.
Jazyk: angličtina
Zdroj: Cancer genetics [Cancer Genet] 2024 Jun; Vol. 284-285, pp. 1-4. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1016/j.cancergen.2024.03.003
Abstrakt: Chromosomal translocation serves as a crucial diagnostic marker in the classification of acute myeloid leukemia. Among the most prevalent cytogenetic abnormalities is t(8;21)(q22;q22), typically associated with the FAB subtype AML-M2. On occasion, alternative forms of t(8;21) have been observed. This report presents a case of AML with RUNX1::RUNX1T1, wherein the karyotype revealed t(2;2;21;8)(p21;q37;q22;q22), representing the first instance of a variant t(8;21) involving both chromosomes 2. The combination of routine karyotype analysis and fluorescence in situ hybridization proves to be an effective method for identifying complex translocations of t(8;21).
Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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