Retinal vascular pathology in a mouse model of Lafora progressive myoclonus epilepsy.

Autor: Patil RP; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Kumar N; Central Experimental Animal Facility, Indian Institute of Technology, Kanpur, India., Kaur A; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Munian RK; Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, India; Department of Mechanical Engineering, Indian Institute of Technology Ropar, India., Bhattacharya B; Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, India., Ganesh S; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India; Central Experimental Animal Facility, Indian Institute of Technology, Kanpur, India; The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, India. Electronic address: sganesh@iitk.ac.in., Parihar R; Central Experimental Animal Facility, Indian Institute of Technology, Kanpur, India. Electronic address: rashmip@iitk.ac.in.
Jazyk: angličtina
Zdroj: Neuroscience research [Neurosci Res] 2024 Jul; Vol. 204, pp. 58-63. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1016/j.neures.2024.02.004
Abstrakt: Neurodegenerative diseases (ND) affect distinct populations of neurons and manifest various clinical and pathological symptoms. A subset of ND prognoses has been linked to vascular risk factors. Consequently, the current study investigated retinal vascular abnormalities in a murine model of Lafora neurodegenerative disease (LD), a fatal and genetic form of progressive myoclonus epilepsy that affects children. Here, arterial rigidity was evaluated by measuring pulse wave velocity and vasculature deformations in the retina. Our findings in the LD mouse model indicate altered pulse wave velocity, retinal vascular thinning, and convoluted retinal arteries.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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