Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?

Autor:	Mokhtar WA; Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Sherief LM; Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Kamal NM; Pediatric Department, Faculty of Medicine, Cairo University, Giza, Egypt., ElSheikh AO; Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Omran FH; Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdulsaboor A; Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Sakr MMH; Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., El Gebally S; Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Shehab MMM; Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Alfaifi J; Department of Child Health, Faculty of Medicine, University of Bisha, Bisha, Kingdom of Saudi Arabia., Turkistani R; Pediatric Department, Alhada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia., Aljuaid F; Pediatric Department, Taif Children Hospital, Taif, Kingdom of Saudi Arabia., Oshi MAM; Neurology Division, Pediatric Department, Gaafar Ibnauf Children's Emergency Hospital, Khartoum, Sudan., Elbekoushi FBA; Pediatric Department, Zagazig University, Zagazig, Egypt., Mokhtar GA; Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Mar 08; Vol. 103 (10), pp. e37356.
DOI:	10.1097/MD.0000000000037356
Abstrakt:	Plasma gelsolin (pGSN) correlates with clinical improvement in septic patients. We aimed to investigate pGSN levels as a diagnostic and prognostic marker of neonatal late-onset-sepsis (LOS). A case-control study was done on 184 neonates (92 with LOS and 92 controls). All participants were subjected to detailed history taking, full clinical evaluation, sepsis workup, and pGSN enzyme-linked immunosorbent-assay measurement. We detected significantly lower pGSN level among cases compared to controls (90.63 ± 20.64 vs 451.83 ± 209.59). It was significantly related to the severity of sepsis and mortality, with significantly lower values among cases with septic shock and multiorgan failure and non-survivors. Follow-up pGSN significantly increased after sepsis improvement in survivors compared to admission values. pGSN might be a reliable diagnostic and prognostic marker for LOS. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu