An acute bout of resistance exercise increases BDNF in hippocampus and restores the long-term memory of insulin-resistant rats.

Autor: Berbert-Gomes C; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil., Ramos JS; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil., Silveira-Rodrigues JG; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil., Leite DMM; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil., Melo BP; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil., Soares DD; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil. danusa56@gmail.com.
Jazyk: angličtina
Zdroj: Experimental brain research [Exp Brain Res] 2024 Apr; Vol. 242 (4), pp. 901-912. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1007/s00221-024-06795-x
Abstrakt: A sedentary lifestyle, inadequate diet, and obesity are substantial risk factors for Type 2 diabetes mellitus (T2DM) development. A major picture of T2DM is insulin resistance (IR), which causes many impairments in brain physiology, such as increased proinflammatory state and decreased brain-derived neurotrophic factor (BDNF) concentration, hence reducing cognitive function. Physical exercise is a non-pharmacological tool for managing T2DM/IR and its complications. Thus, this study investigated the effects of IR induction and the acute effects of resistance exercise (RE) on memory, neurotrophic, and inflammatory responses in the hippocampus and prefrontal cortex of insulin-resistant rats. IR was induced by a high-fat diet and fructose-rich beverage. Insulin-resistant rats performed acute resistance exercise (IR.RE; vertical ladder climb at 50-100% of the maximum load) or rest (IR.REST; 20 min). Cognitive parameters were assessed by novel object recognition (NOR) tasks, and biochemical analyses were performed to assess BDNF concentrations and inflammatory profile in the hippocampus and prefrontal cortex. Insulin-resistant rats had 20% worse long-term memory (LTM) (p < 0.01) and lower BDNF concentration in the hippocampus (-14.6%; p < 0.05) when compared to non-insulin-resistant rats (CON). An acute bout of RE restored LTM (-9.7% pre vs. post; p > 0.05) and increased BDNF concentration in the hippocampus (9.1%; p < 0.05) of insulin-resistant rats compared to REST. Thus, an acute bout of RE can attenuate the adverse effects of IR on memory and neurotrophic factors in rats, representing a therapeutic tool to alleviate the IR impact on the brain.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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