A Perspective Review on Diet Quality, Excess Adiposity, and Chronic Psychosocial Stress and Implications for Early-Onset Colorectal Cancer.

Autor:	Oliveira ML; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, United States. Electronic address: mlimao2@uic.edu., Biggers A; College of Medicine, University of Illinois at Chicago, Chicago, IL, United States., Oddo VM; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, United States., Yanez B; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Booms E; Department of Biology, Northeastern Illinois University, Chicago, IL, United States., Sharp L; Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL, United States., Naylor K; College of Medicine, University of Illinois at Chicago, Chicago, IL, United States., Wolf PG; Department of Nutrition Science, Purdue University, West Lafayette, IN, United States., Tussing-Humphreys L; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2024 Apr; Vol. 154 (4), pp. 1069-1079. Date of Electronic Publication: 2024 Mar 06.
DOI:	10.1016/j.tjnut.2024.03.002
Abstrakt:	Colorectal cancer (CRC) is the third most common cancer worldwide. Although the overall incidence of CRC has been decreasing over the past 40 y, early-onset colorectal cancer (EOCRC), which is defined as a CRC diagnosis in patients aged >50 y has increased. In this Perspective, we highlight and summarize the association between diet quality and excess adiposity, and EOCRC. We also explore chronic psychosocial stress (CPS), a less investigated modifiable risk factor, and EOCRC. We were able to show that a poor-quality diet, characterized by a high intake of sugary beverages and a Western diet pattern (high intake of red and processed meats, refined grains, and foods with added sugars) can promote risk factors associated with EOCRC development, such as an imbalance in the composition and function of the gut microbiome, presence of chronic inflammation, and insulin resistance. Excess adiposity, particularly obesity onset in early adulthood, is a likely contributor of EOCRC. Although the research is sparse examining CPS and CRC/EOCRC, we describe likely pathways linking CPS to tumorigenesis. Although additional research is needed to understand what factors are driving the uptick in EOCRC, managing body weight, improving diet quality, and mitigating psychosocial stress, may play an important role in reducing an individual's risk of EOCRC. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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