In-Vivo Evaluation of a Novel Integrated Pediatric Pump Lung in a 30-Day Ovine Animal Model.

Autor:	Leibowitz JL; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Awad MA; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Han D; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Shah A; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Sun W; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Zhang J; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Griffith BP; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD., Wu ZJ; From the Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.; Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, MD.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2024 Aug 01; Vol. 70 (8), pp. 704-712. Date of Electronic Publication: 2024 Mar 06.
DOI:	10.1097/MAT.0000000000002173
Abstrakt:	Recently there has been increased use of mechanical circulatory support in pediatric patients as a bridge to cardiopulmonary recovery or transplantation. However, there are few devices that are optimized and approved for use in pediatric patients. We designed and prototyped a novel integrated pediatric pump lung (PPL) that underwent 30 day in-vivo testing in seven juvenile Dorset Hybrid sheep. Devices were implanted in a right atrial to pulmonary artery configuration. Six of seven sheep survived with a device functioning for 25-35 days. The device flow rate was maintained at 2.08 ± 0.34 to 2.54 ± 0.16 L/min with oxygen transfer of 109.8 ± 24.8 to 151.2 ± 26.2 ml/min over the study duration. Aside from a postoperative drop in hematocrit, all hematologic and blood chemistry test values returned to normal ranges after 1-2 weeks postoperatively. Similarly, lactate dehydrogenase increased postoperatively and returned to baseline. In two sheep, there were early device failures due to oxygenator thrombosis on postoperative days zero and five; they then had oxygenator exchanges with subsequent devices performing stably for 30 days. This study demonstrated that the integrated PPL device exhibited stable performance and acceptable biocompatibility in a 30 day ovine model. Competing Interests: Disclosure: Z.J.W. and B.P.G. disclose financial interest in Abiomed-Breethe, Inc. and intellectual property for ECMO systems and blood pumps. A.S. discloses consulting for Abiomed, Inc. and has intellectual property in ECMO cannulas. J.Z. discloses financial interest in intellectual property for ECMO systems and blood pumps. Z.J.W. serves as a consultant for Daiichi Sankyo, Inc. and CH Biomedical USA, Inc. The other authors have no conflicts of interest to report. (Copyright © ASAIO 2024.)
Databáze:	MEDLINE
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