Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease.

Autor: Machfer A; Research Laboratory: Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax, Tunisia. amalmachfer@gmail.com., Bouzid MA; Research Laboratory: Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax, Tunisia., Fekih N; Research Laboratory: Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax, Tunisia., Hassen HBH; Research Laboratory: Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax, Tunisia., Amor HH; Department of Cardiology, Tahar Sfar Hospital, Mahdia, Tunisia., Tagougui S; Université de Lille, Université d'Artois, Université du Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France.; Montreal Clinical Research Institute (IRCM), Montreal, Canada., Chtourou H; Activité Physique, Sport et Santé, UR18JS01, Observatoire National du Sport, 1003, Tunis, Tunisia.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2024 Jul; Vol. 56 (7), pp. 2411-2419. Date of Electronic Publication: 2024 Mar 05.
DOI: 10.1007/s11255-024-03991-0
Abstrakt: Purpose: The aims of this study were to compare cerebral hemodynamics and maximal oxygen uptake (VO 2peak ) in patients with end-stage renal disease (ESRD) vs. age-matched healthy controls during maximal exercise.
Methods: Twelve patients with ESRD and twelve healthy adults (CTR group) performed exhaustive incremental exercise test. Throughout the exercise test, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O 2 Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the prefrontal cortex.
Results: Compared to CTR, VO 2peak was significantly lower in ESRD group (P < 0.05). Increase in ∆THb (i.e., cerebral blood volume) was significantly blunted in ESRD (P < 0.05). ESRD patients also had impaired changes in cerebral ∆HHb and ∆O 2 Hb during high intensity of exercise (P < 0.05). Finally, no significant correlation was observed between VO 2peak and changes in cerebral hemodynamics parameters in both groups (All P > 0.05).
Conclusion: Maximal exercise highlights subtle disorders of both hemodynamics and neuronal oxygenation in the prefrontal cortex in patients with ESRD. This may contribute to both impaired cognitive function and reduced exercise tolerance throughout the progression of the disease.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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