The impact of heart valve and partial heart transplant models on the development of banking methods for tissues and organs: A concise review.

Autor: Vogel AD; Department of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, AR, USA; Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA., Suk R; Department of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, AR, USA; Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA., Haran C; Department of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, AR, USA; Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA., Dickinson PG; Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA., Helke KL; Medical University of South Carolina, Charleston, SC, USA., Hassid M; Medical University of South Carolina, Charleston, SC, USA., Fitzgerald DC; Medical University of South Carolina, Charleston, SC, USA., Turek JW; Department of Surgery, Duke University, Durham, NC, USA., Brockbank KGM; Medical University of South Carolina, Charleston, SC, USA; Tissue Testing Technologies LLC, North Charleston, SC, USA; Department of Bioengineering, Clemson University at Charleston, SC, USA., Rajab TK; Department of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, AR, USA. Electronic address: tkrajab@uams.edu.
Jazyk: angličtina
Zdroj: Cryobiology [Cryobiology] 2024 Jun; Vol. 115, pp. 104880. Date of Electronic Publication: 2024 Mar 02.
DOI: 10.1016/j.cryobiol.2024.104880
Abstrakt: Cryopreserved human heart valves fill a crucial role in the treatment for congenital cardiac anomalies, since the use of alternative mechanical and xenogeneic tissue valves have historically been limited in babies. Heart valve models have been used since 1998 to better understand the impact of cryopreservation variables on the heart valve tissue components with the ultimate goals of improving cryopreserved tissue outcomes and potentially extrapolating results with tissues to organs. Cryopreservation traditionally relies on conventional freezing, employing cryoprotective agents, and slow cooling to sub-zero centigrade temperatures; but it is plagued by the formation of ice crystals and cell damage upon thawing. Researchers have identified ice-free vitrification procedures and developed a new rapid warming method termed nanowarming. Nanowarming is an emerging method that utilizes targeted application of energy at the nanoscale level to rapidly rewarm vitrified tissues, such as heart valves, uniformly for transplantation. Vitrification and nanowarming methods hold great promise for surgery, enabling the storage and transplantation of tissues for various applications, including tissue repair and replacement. These innovations have the potential to revolutionize complex tissue and organ transplantation, including partial heart transplantation. Banking these grafts addresses organ scarcity by extending preservation duration while preserving biological activity with maintenance of structural fidelity. While ice-free vitrification and nanowarming show remarkable potential, they are still in early development. Further interdisciplinary research must be dedicated to exploring the remaining challenges that include scalability, optimizing cryoprotectant solutions, and ensuring long-term viability upon rewarming in vitro and in vivo.
Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest with the exception of KGMB who is an owner and employee of Tissue Testing Technologies LLC. The Company is developing procedures for banking of tissues for clinical applications.
(Copyright © 2024 Society for Cryobiology. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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