Successful Treatment of a Case of Crescentic Glomerulonephritis in a Patient with Primary Peritoneal Carcinoma: A case report.
| Autor: | Zribi A; Women Health Program and., Nagy A; Department of Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Centre, Muscat, Oman., Riyami MA; Department of Pathology, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman., Burney IA; Women Health Program and. |
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| Jazyk: | angličtina |
| Zdroj: | Sultan Qaboos University medical journal [Sultan Qaboos Univ Med J] 2024 Feb; Vol. 24 (1), pp. 119-122. Date of Electronic Publication: 2022 Sep 11. |
| DOI: | 10.18295/squmj.1.2023.013 |
| Abstrakt: | Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min. The patient received two doses of rituximab and three doses of pulse corticosteroids, leading to significant improvement in renal function and the disappearance of her proteinuria. The eGFR improved to >60mL/min; her proteinuria gradually resolved after 10 weeks of treatment. She was then given a combination chemotherapy treatment for tubo-ovarian/peritoneal cancer leading to a normalisation of her CA-125 after three months of therapy. (© Copyright 2024, Sultan Qaboos University Medical Journal, All Rights Reserved.) |
| Databáze: | MEDLINE |
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