Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction.

Autor: Candreva A; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico Di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy.; Department of Cardiology, Zurich University Hospital, Zurich, Switzerland., Lodi Rizzini M; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico Di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy., Calò K; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico Di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy., Pagnoni M; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland., Munhoz D; Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium., Chiastra C; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico Di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy., Aben JP; Pie Medical Imaging, Maastricht, Netherlands., Fournier S; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland., Muller O; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland., De Bruyne B; Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium., Collet C; Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium., Gallo D; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico Di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy., Morbiducci U; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico Di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy. umberto.morbiducci@polito.it.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2024 Aug; Vol. 17 (4), pp. 893-900. Date of Electronic Publication: 2024 Mar 01.
DOI: 10.1007/s12265-024-10500-2
Abstrakt: This study focuses on identifying anatomical markers with predictive capacity for long-term myocardial infarction (MI) in focal coronary artery disease (CAD). Eighty future culprit lesions (FCL) and 108 non-culprit lesions (NCL) from 80 patients underwent 3D quantitative coronary angiography. The minimum lumen area (MLA), minimum lumen ratio (MLR), and vessel fractional flow reserve (vFFR) were evaluated. MLR was defined as the ratio between MLA and the cross-sectional area at the proximal lesion edge, with lower values indicating more abrupt luminal narrowing. Significant differences were observed between FCL and NCL in MLR (0.41 vs. 0.53, p < 0.001). MLR correlated inversely with translesional vFFR (r =  - 0.26, p = 0.0004) and was the strongest predictor of MI at 5 years (AUC = 0.75). Lesions with MLR < 0.40 had a fourfold increased MI incidence at 5 years. MLR is a robust predictor of future adverse coronary events.
(© 2024. The Author(s).)
Databáze: MEDLINE
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