[Steroid-Dependent Nephrotic Syndrome Due to Minimal Change Glomerulonephritis Treated with Rituximab].

Autor:	Cristiano F; UOSD Nefrologia Dialisi, Ospedale di Ortona, Contrada Santa Liberata ‒ Asl 2 Lanciano Vasto Chieti., Verratti V; Department of Psychological, Health and Territorial Sciences, University 'G. d'Annunzio' of Chieti-Pescara, Chieti., Di Matteo G; Department of Neuroscience, Imaging and Clinical Science, G. D'Annunzio University of Chieti-Pescara., Fulle S; Department of Neuroscience, Imaging and Clinical Science, G. D'Annunzio University of Chieti-Pescara., Cristiano J; UOC Farmacia Ospedaliera - Ospedale Clinicizzato di Chieti - Asl 2 Lanciano Vasto Chieti., D'Angelo B; UOSD Nefrologia Dialisi, Ospedale di Ortona, Contrada Santa Liberata ‒ Asl 2 Lanciano Vasto Chieti., Caravelli L; UOSD Nefrologia Dialisi, Ospedale di Ortona, Contrada Santa Liberata ‒ Asl 2 Lanciano Vasto Chieti., Posari C; UOSD Nefrologia Dialisi, Ospedale di Ortona, Contrada Santa Liberata ‒ Asl 2 Lanciano Vasto Chieti., Schiazza A; UOSD Nefrologia Dialisi, Ospedale di Ortona, Contrada Santa Liberata ‒ Asl 2 Lanciano Vasto Chieti., Piano A; UOSD Nefrologia Dialisi, Ospedale di Ortona, Contrada Santa Liberata ‒ Asl 2 Lanciano Vasto Chieti.
Jazyk:	italština
Zdroj:	Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2024 Feb 28; Vol. 41 (1). Date of Electronic Publication: 2024 Feb 28.
Abstrakt:	47-year-old woman suffering from minimal lesion glomerulonephritis previously undergone high-dose steroid therapy and subjected to exacerbations of nephrotic syndrome after therapy discontinuation. It was decided to initiate off-label treatment with Rituximab at a dosage of 375 mg/m2 administred at zero-time, one-month and three months with good therapeutic response and resolution of the clinical laboratory picture. The therapy was well tolerated and had no side effects. This scheme could be an alternative to the conventional therapeutic scheme with steroids or other classes of immunosuppressive drugs, especially in order to avoid problems related to prolonged exposure to steroid therapy. (Copyright by Società Italiana di Nefrologia SIN, Rome,Italy.)
Databáze:	MEDLINE
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