Reactance inversion in moderate to severe persistent asthma: low birth weight, prematurity effect, and bronchodilator response.

Autor: González Vera R; Clínica Las Condes, Santiago, Chile., Vidal Grell A; Clínica MEDS, Santiago, Chile., Castro-Rodríguez JA; Pontificia Universidad Católica de Chile, Santiago, Chile., Palomino Montenegro MA; Clínica Las Condes, Universidad de Chile, Santiago, Chile., Méndez Yarur A; Clínica MEDS, Santiago, Chile.
Jazyk: angličtina
Zdroj: The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2024 Sep; Vol. 61 (9), pp. 1076-1082. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1080/02770903.2024.2324865
Abstrakt: Introduction: Reactance inversion (RI) has been associated with impaired peripheral airway function in persistent asthma. However, there is little to no data about the difference between asthmatic children with and without RI. This study aimed to detect clinical and lung function differences in moderate-severe asthmatic children with and without RI.
Methods: This study was conducted between 2021 and 2022 in asthmatic school-age children. Impulse oscillometry (IOS) and spirometry were performed according to ATS/ERS standards.
Results: A total of 62 patients, with a mean age of 8.4 years, 54.8% were males and were divided into three groups: group 1 (32.3%) with no RI, group 2 (27.4%) with RI but disappearing after bronchodilator test and group 3 (40.3%) with persistent RI after bronchodilator test. Children in groups 2 and 3 had significantly lower birth weights than in group 1. Group 2 had lower gestational age compared to group 1. FEV 1 and FEF 25-75 of forced vital capacity were significantly lower in groups 2 and 3. In group 3, R5, AX, R5-20, and R5-R20/R5 ratios were significantly higher. Bronchodilator responses (BDR) in X5c, AX, and R5-R20 were significantly different between groups and lower in group 3.
Conclusion: RI is frequently found in children with moderate-severe persistent asthma, particularly in those with a history of prematurity or low birth weight. In some patients, RI disappears after the bronchodilator test; however, it, persists in those with the worst pulmonary function. RI could be a small airway dysfunction marker.
Databáze: MEDLINE
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