Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon.

Autor: Sales CA; Universidade Federal do Pará, Faculdade de Farmácia, Laboratório de Toxicologia, Belém, PA, Brasil., Pinto-Silva MCF; Universidade Federal do Pará, Faculdade de Farmácia, Laboratório de Toxicologia, Belém, PA, Brasil., Bardález-Rivera JG; Universidade Federal do Pará, Faculdade de Farmácia, Laboratório de Toxicologia, Belém, PA, Brasil., Abreu-Alberio CA; Universidade Federal do Pará, Faculdade de Farmácia, Laboratório de Toxicologia, Belém, PA, Brasil., Sena LWP; Universidade Federal do Sul e Sudeste do Pará, Faculdade de Saúde Pública, Marabá, PA, Brasil., Vieira JLF; Universidade Federal do Pará, Faculdade de Farmácia, Laboratório de Toxicologia, Belém, PA, Brasil.
Jazyk: angličtina
Zdroj: Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2024 Feb 26; Vol. 83, pp. e272512. Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024).
DOI: 10.1590/1519-6984.272512
Abstrakt: This study aimed to correlate the values of liver markers with oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon. A total of 30 patients from the Tuberculosis clinic of a referral hospital were admitted to the study. Whole blood samples were collected for analysis of liver enzyme values and oxidative stress markers by spectrophotometry. The prevalence was male (60%) and the 18-29 age group was the most affected. Patients with multidrug-resistant tuberculosis presented catalase values with a median equal to 6.94 U/gHb and for glutathione, the median was equal to 14.76 µg∕ml. As for the values of liver enzymes (AST, ALT, Gamma-GT and Alkaline phosphatase) the patients had medians equal to 60.50 (U/L); 80 (U/L); 54 (U/L); and 100 (U/L) respectively (p<0.0001). The results suggest a hepatotoxic effect of the drug, which recommends further studies with a larger number of samples in order to investigate the predictors of liver damage in patients with multidrug-resistant tuberculosis.
Databáze: MEDLINE
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