A new linear peptide, higapeptin, isolated from the mud flat-derived fungus Acremonium persicinum inhibits mitochondrial energy metabolism.

Autor: El-Desoky AH; Pharmaceutical and Drug Industries Research Institute, Pharmacognosy Department, National Research Centre, 33 El-Bohouth St., Dokki, 12622, Giza, Egypt., Hitora Y; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto, 862-0973, Japan., Nishime Y; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto, 862-0973, Japan., Sadahiro Y; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto, 862-0973, Japan., Kawahara T; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto, 862-0973, Japan., Tsukamoto S; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto, 862-0973, Japan. sachiko@kumamoto-u.ac.jp.
Jazyk: angličtina
Zdroj: Journal of natural medicines [J Nat Med] 2024 Jun; Vol. 78 (3), pp. 505-513. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.1007/s11418-024-01784-4
Abstrakt: A combination of LC-MS/MS and feature-based molecular networking analyses led to the isolation of a new adenopeptin analog, higapeptin (1), and four known peptides, adenopeptin (2), adenopeptins B and C (3 and 4), and acremopeptin (5), from the rice culture of the fungus Acremonium persicinum (18F04103) isolated from a mud flat of the Ariake Sea in Kyushu, Japan. The structure of 1 was determined by NMR and MS/MS fragmentation analyses. The absolute configuration of the constituent amino acids was determined by Marfey's analysis after acid hydrolysis. The C-terminal residue was synthesized, and its absolute configuration was established by Marfey's analysis. Compounds 1 and 2 were found to inhibit mitochondrial energy metabolism, similar to efrapeptin D (6), a known mitochondrial ATPase inhibitor.
(© 2024. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.)
Databáze: MEDLINE
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