Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study.

Autor: Reutrakul S; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA. sreutrak@uic.edu., Park JC; Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, USA., McAnany JJ; Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, USA., Chau FY; Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, USA., Danielson KK; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Prasad B; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Jessie Brown Department of Veterans Affairs Hospital, Chicago, IL, USA., Cross A; Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, USA., Sintetas S; Section of Adult and Pediatric Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA., Law J; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Pannain S; Section of Adult and Pediatric Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA., Pratuangtham S; Section of Adult and Pediatric Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA., Van Cauter E; Section of Adult and Pediatric Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA., Hanlon EC; Section of Adult and Pediatric Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: Diabetologia [Diabetologia] 2024 Jun; Vol. 67 (6), pp. 1114-1121. Date of Electronic Publication: 2024 Feb 27.
DOI: 10.1007/s00125-024-06118-3
Abstrakt: Aims/hypothesis: The aim of this study was to explore whether diabetic retinopathy is associated with alterations of the circadian system, and to examine the role of reduced intrinsically photosensitive retinal ganglion cell (ipRGC) function.
Methods: Participants with type 2 diabetes, with diabetic retinopathy (n=14) and without diabetic retinopathy (n=9) underwent 24 h blood sampling for melatonin and cortisol under controlled laboratory conditions. ipRGC function was inferred from the post-illumination pupil response (PIPR). Habitual sleep duration, efficiency and variability were assessed by actigraphy.
Results: Participants with diabetic retinopathy compared to participants without diabetic retinopathy had smaller PIPR (p=0.007), lower 24 h serum melatonin output (p=0.042) and greater day-to-day sleep variability (p=0.012). By contrast, 24 h cortisol profiles, sleep duration and efficiency were similar in both groups. Six individuals with diabetic retinopathy had no detectable dim-light melatonin onset. PIPR correlated with 24 h mean melatonin levels (r=0.555, p=0.007).
Conclusions/interpretation: ipRCG dysfunction in diabetic retinopathy is associated with disruptions of the 24 h melatonin rhythm, suggesting circadian dysregulation in diabetic retinopathy.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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