Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial.

Autor: Pietrzak M; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Department of Psychiatry, Linköping University Hospital, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Yngve A; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Hamilton JP; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden.; Department of Medical and Biological Psychology, University of Bergen, Bergen, 5007, Norway., Asratian A; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Gauffin E; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Department of Psychiatry, Linköping University Hospital, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Löfberg A; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Department of Psychiatry, Linköping University Hospital, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Gustavson S; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Department of Psychiatry, Linköping University Hospital, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Persson E; Division of Economics, Department of Management and Engineering, Linköping University, Linköping, 58183, Sweden., Capusan AJ; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Department of Psychiatry, Linköping University Hospital, Linköping, 58183, Sweden., Leggio L; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, 21224, USA., Perini I; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Tinghög G; Division of Economics, Department of Management and Engineering, Linköping University, Linköping, 58183, Sweden.; National Center for Health Care Priority Setting, Department of Health Medicine and Caring Sciences, Linköping University, 58183, Linköping, Sweden., Heilig M; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.; Department of Psychiatry, Linköping University Hospital, Linköping, 58183, Sweden.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden., Boehme R; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden. Rebecca.bohme@liu.se.; Center for Medical Imaging and Visualization, Linköping University, Linköping, 58183, Sweden. Rebecca.bohme@liu.se.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 May; Vol. 49 (6), pp. 1042-1049. Date of Electronic Publication: 2024 Feb 26.
DOI: 10.1038/s41386-024-01821-6
Abstrakt: The stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and survival, but it has been suggested to also be involved in the stress response, in neuropsychiatric conditions, and in alcohol and drug use disorders. Mechanisms related to reward processing might mediate ghrelin's broader effects on complex behaviors, as indicated by animal studies and mostly correlative human studies. Here, using a within-subject double-blind placebo-controlled design with intravenous ghrelin infusion in healthy volunteers (n = 30), we tested whether ghrelin alters sensitivity to reward and punishment in a reward learning task. Parameters were derived from a computational model of participants' task behavior. The reversal learning task with monetary rewards was performed during functional brain imaging to investigate ghrelin effects on brain signals related to reward prediction errors. Compared to placebo, ghrelin decreased punishment sensitivity (t = -2.448, p = 0.021), while reward sensitivity was unaltered (t = 0.8, p = 0.43). We furthermore found increased prediction-error related activity in the dorsal striatum during ghrelin administration (region of interest analysis: t-values ≥ 4.21, p-values ≤ 0.044). Our results support a role for ghrelin in reward processing that extends beyond food-related rewards. Reduced sensitivity to negative outcomes and increased processing of prediction errors may be beneficial for food foraging when hungry but could also relate to increased risk taking and impulsivity in the broader context of addictive behaviors.
(© 2024. The Author(s).)
Databáze: MEDLINE
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