Prescribing patterns of antimicrobials according to the WHO AWaRe classification at a tertiary referral hospital in the southern highlands of Tanzania.

Autor:	Nsojo A; Mbeya College of Health and Allied Sciences, University of Dar es Salaam, P. O. Box 608, Mbeya, Tanzania.; Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania., George L; Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania., Mwasomola D; Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania., Tawete J; Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania., Mbotwa CH; Mbeya College of Health and Allied Sciences, University of Dar es Salaam, P. O. Box 608, Mbeya, Tanzania., Mweya CN; Mbeya College of Health and Allied Sciences, University of Dar es Salaam, P. O. Box 608, Mbeya, Tanzania.; Mbeya Medical Research Centre, National Institute for Medical Research, P. O. Box 2410, Mbeya, Tanzania., Mwakyula I; Mbeya College of Health and Allied Sciences, University of Dar es Salaam, P. O. Box 608, Mbeya, Tanzania.; Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania.
Jazyk:	angličtina
Zdroj:	Infection prevention in practice [Infect Prev Pract] 2024 Feb 06; Vol. 6 (2), pp. 100347. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024).
DOI:	10.1016/j.infpip.2024.100347
Abstrakt:	Background: Antimicrobial consumption continues to rise globally and contributes to the emergence and spread of antimicrobial resistance. This study aimed to evaluate antimicrobial prescribing patterns in a selected tertiary hospital in Tanzania. Methods: This cross-sectional study was conducted for one year (September 2021-September 2022) at Mbeya Zonal Referral Hospital, a public hospital in the southern highlands zone of Tanzania. Data on clinical diagnosis, laboratory tests, prescribed antimicrobials, and prescribers' designations were collected through a custom eMedical system, aligning antimicrobials with the WHO's 2021 AWaRe classification. Descriptive analysis was performed to assess the pattern of antimicrobial prescriptions. Results: Of 2,293 antimicrobial prescriptions, 62.41% were ACCESS, 37.42% were WATCH, and 0.17% fell in the RESERVE categories. Metronidazole, accounting for 23.8%, was the most commonly prescribed antimicrobial. More than 50% of the ACCESS and WATCH prescriptions were justified by laboratory diagnosis and were predominantly prescribed by clinicians. A very small proportion of prescriptions (<1%) were informed by culture and sensitivity (C/S) testing. The Paediatric department had the majority of WATCH prescriptions (72.2%). Conclusion: The prescribing patterns at the study hospital generally align with WHO AWaRe guidelines, potentially mitigating antimicrobial resistance. Nevertheless, the scarcity of culture and sensitivity testing is a concern that warrants targeted improvement. (© 2024 Published by Elsevier Ltd on behalf of The Healthcare Infection Society.)
Databáze:	MEDLINE
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