Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia.

Autor:	Mo F; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China., Zhao H; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China., Li Y; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China., Cai H; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China., Song Y; Department of Pain, The First Affiliated Hospital of Anhui Medical University, Hefei, China., Wang R; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China., Yu Y; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China., Zhu J; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China.; Anhui Provincial Institute of Translational Medicine, Hefei, China.; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, China.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin [Schizophr Bull] 2024 Nov 08; Vol. 50 (6), pp. 1326-1336.
DOI:	10.1093/schbul/sbae020
Abstrakt:	Background and Hypothesis: Neuroimaging studies investigating the neural substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed results, which may be reconciled by network localization. We sought to examine whether AVH-state and AVH-trait brain alterations in schizophrenia localize to common or distinct networks. Study Design: We initially identified AVH-state and AVH-trait brain alterations in schizophrenia reported in 48 previous studies. By integrating these affected brain locations with large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we then leveraged novel functional connectivity network mapping to construct AVH-state and AVH-trait dysfunctional networks. Study Results: The neuroanatomically heterogeneous AVH-state and AVH-trait brain alterations in schizophrenia localized to distinct and specific networks. The AVH-state dysfunctional network comprised a broadly distributed set of brain regions mainly involving the auditory, salience, basal ganglia, language, and sensorimotor networks. Contrastingly, the AVH-trait dysfunctional network manifested as a pattern of circumscribed brain regions principally implicating the caudate and inferior frontal gyrus. Additionally, the AVH-state dysfunctional network aligned with the neuromodulation targets for effective treatment of AVH, indicating possible clinical relevance. Conclusions: Apart from unifying the seemingly irreproducible neuroimaging results across prior AVH studies, our findings suggest different neural mechanisms underlying AVH state and trait in schizophrenia from a network perspective and more broadly may inform future neuromodulation treatment for AVH. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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