Intermittent fasting associated with coconut oil (Cocos nucifera L.) alters gut-liver axis parameters in diet-induced obese rats.

Autor: de Souza DM; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil., Cavalcante HC; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil., Dos Santos Lima M; Postgraduate Program in Food Science and Technology, Federal University of Paraíba, João Pessoa, Brazil; Food and Beverage Analysis Laboratory, Department of Food Technology, Instituto Federal do Sertão Pernambucano, Petrolina, Brazil., Alves AF; Pathology Laboratory, Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa, Brazil., da Veiga Dutra ML; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil., D'Oliveira AB; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil., Vasconcelos de Araújo AN; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil., Gomes Dutra LM; Postgraduate Program in Food Science and Technology, Federal University of Paraíba, João Pessoa, Brazil., Batista KS; Semiarid National Institute (Instituto Nacional do Semiárido - INSA), Campina Grande, Brazil., de Souza Aquino J; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Food Science and Technology, Federal University of Paraíba, João Pessoa, Brazil. Electronic address: jailane.aquino@academico.ufpb.br.
Jazyk: angličtina
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2024 May; Vol. 121, pp. 112370. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1016/j.nut.2024.112370
Abstrakt: Objective: The aim of this article is to investigate the effect of intermittent fasting, associated or not with coconut oil intake, on the gut-liver axis of obese rats.
Methods: A total of 50 rats were divided into five groups: control, obese, obese with intermittent fasting, obese with intermittent fasting plus coconut oil, and obese with caloric restriction. The rats were induced to obesity with a high-sugar diet for 17 wk. The respective interventions were carried out in the last 4 wk.
Results: The groups with intermittent fasting protocols had reduced total cholesterol (on average 54.31%), low-density lipoprotein (on average 53.39%), and triacylglycerols (on average 23.94%) versus the obese group; and the obese with intermittent fasting plus coconut oil group had the highest high-density lipoprotein compared with all groups. The obese with intermittent fasting plus coconut oil and obese with caloric restriction groups had lower metabolic load compared with the other groups. The obese group had high citric and succinic acid concentrations, which affected the hepatic tricarboxylic acid cycle, while all the interventions had reduced concentrations of these acids. No histologic changes were observed in the intestine or liver of the groups.
Conclusion: Intermittent fasting, especially when associated with coconut oil, had effects comparable with caloric restriction in modulating the parameters of the gut-liver axis.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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