Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach.

Autor: Isenmann E; Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.; Department of Fitness and Health, IST University of Applied Sciences, Dusseldorf, Germany., Yuliandra T; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany., Touvleliou K; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany., Broekmann M; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.; Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., de la Torre X; Laboratorio Antidoping FMSI, Rome, Italy., Botrè F; Laboratorio Antidoping FMSI, Rome, Italy.; REDs-Research and Expertise in Anti-Doping Sciences, ISSUL-Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland., Diel P; Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany., Parr MK; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.
Jazyk: angličtina
Zdroj: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Jun; Vol. 357 (6), pp. e2300689. Date of Electronic Publication: 2024 Feb 24.
DOI: 10.1002/ardp.202300689
Abstrakt: The phytosteroid ecdysterone is classified as an anabolic agent and has been included on the monitoring list of the World Anti-Doping Agency since 2020. Therefore, the consumption of food rich in ecdysterone, such as quinoa and spinach, is the focus of a lively debate. Thus, the urinary excretion of ecdysterone and its metabolites in humans was investigated following quinoa consumption alone and in combination with spinach. Eight participants (four male and four female) were included, and they ingested 368 ± 61 g cooked quinoa alone and in combination with 809 ± 115 g spinach after a washout. Post-administration urines were analyzed by LC-MS/MS. After intake of both preparations, ecdysterone and two metabolites were excreted in the urine. The maximum concentration of ecdysterone ranged from 0.44 to 5.5 µg/mL after quinoa and from 0.34 to 4.1 µg/mL after quinoa with spinach. The total urinary excreted amount as parent drug plus metabolites was 2.61 ± 1.1% following quinoa intake and 1.7 ± 0.9% in combination with spinach. Significant differences were found in the total urinary excreted amount of ecdysterone, 14-deoxy-ecdysterone, and 14-deoxy-poststerone. Only small portions of ecdysterone from quinoa and the combination with spinach were excreted in the urine, suggesting that both quinoa and spinach are poor sources of ecdysterone in terms of bioavailability.
(© 2024 The Authors. Archiv der Pharmazie published by Wiley‐VCH GmbH on behalf of Deutsche Pharmazeutische Gesellschaft.)
Databáze: MEDLINE
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