Phytochemical and Micro-Morphological Characterization of Atraphaxis pyrifolia Bunge Growing in the Republic of Kazakhstan.

Autor: Abilkassymova A; Higher School of Medicine, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.; School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA., Kozykeyeva R; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.; Department of Pharmacognosy, Faculty of Pharmacy, South Kazakhstan Medical Academy, Shymkent 160019, Kazakhstan., Aldana-Mejía JA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA., John Adams S; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA., Datkhayev U; School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan., Turgumbayeva A; Higher School of Medicine, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.; School of Life Sciences, University of Westminster, London W1W 6UW, UK., Orynbassarova K; Department of Pharmacognosy, Faculty of Pharmacy, South Kazakhstan Medical Academy, Shymkent 160019, Kazakhstan., Saroja SG; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA., Khan IA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.; Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA., Ross SA; School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.; Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 13; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 13.
DOI: 10.3390/molecules29040833
Abstrakt: Atraphaxis pyrifolia is a native species of Central Asia, known for curing several disorders. The species has little knowledges about its chemical composition and any information about its morphological characteristics despite its importance in traditional Asian medicine. This is one of the first approaches to the phytochemical and morphological characterization of this species. Micro-morphology was performed on the stem, and leaf parts of this plant to profile the morpho-anatomical characters using brightfield, fluorescence, polarized and scanning electron microscopy. Leaves were extracted with hexane and methanol. The hexane extract was analyzed using GC-MS analysis revealing the major presence of γ-sitosterol and nonacosane. The methanolic extract was submitted to Vacuum Liquid Chromatography and Sephadex LH-20. HPTLC, HR-ESI-MS and NMR techniques were used to identify the main compounds. Four glycosylated flavonoids were isolated: 8- O -acetyl-7- O -methyl-3- O -α-l-rhamnopyranosylgossypetin (Compound 1 ), and 7- O -methyl-3- O -α-l-rhamnopyranosylgossypetin (Compound 3 ), and two other compounds reported for the first time in the literature (Compounds 2 and 4 ). The findings presented herein furnish pertinent information essential for the identification and authentication of this medicinal plant. Such insights are invaluable for facilitating robust quality control measures and serve as a foundational framework for subsequent endeavours in metabolic, pharmacological, and taxonomical analyses.
Databáze: MEDLINE
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