| Autor: |
Kharbat AF; Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Balasubramanian K; Division of Neurosurgery, Texas A&M University College of Medicine, Bryan, TX 77807, USA., Sankarappan K; Division of Neurosurgery, Texas A&M University College of Medicine, Bryan, TX 77807, USA., Morgan RD; Division of Neurosurgery, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA., Hassan KM; Department of Neurosurgery, King Edward Medical University, Lahore 54000, Pakistan., Palmisciano P; Department of Neurosurgery, University of California Davis, Davis, CA 95616, USA., Pelargos PE; Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Chukwu M; Department of Surgery, New York Presbyterian Hospital/Weill Cornell, New York, NY 10065, USA., Bin Alamer O; Department of Neurosurgery, University of Pittsburg Medical Center, Pittsburg, PA 15219, USA., Haider AS; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., El Ahmadieh TY; Department of Neurosurgery, Loma Linda University, Loma Linda, CA 92354, USA., Burke JF; Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
| Abstrakt: |
The study cohort consisted of 83 patients with a mean age of 49.55 (SD 13.72) with a female preponderance (60 patients). Here, 32.14% of patients had primary LTS; the remaining were metastases. Clinical presentation included nonspecific back pain (57.83%), weakness (21.69%) and radicular pain (18.07%). History of uterine neoplasia was found in 33.73% of patients. LTS preferentially affected the thoracic spine (51.81%), followed by the lumbar (21.67%) spine. MRI alone was the most common imaging modality (33.33%); in other cases, it was used with CT (22.92%) or X-ray (16.67%); 19.23% of patients had Resection/Fixation, 15.38% had Total en bloc spondylectomy, and 10.26% had Corpectomy. A minority of patients had laminectomy and decompression. Among those with resection, 45.83% had a gross total resection, 29.17% had a subtotal resection, and 16.67% had a near total resection. Immunohistochemistry demonstrated positivity for actin (43.37%), desmin (31.33%), and Ki67 (25.30). At a follow-up of 19.3 months, 61.97% of patients were alive; 26.25% of 80 patients received no additional treatment, 23.75% received combination radiotherapy and chemotherapy, only chemotherapy was given to 20%, and radiotherapy was given to 17.5%. Few (2.5%) had further resection. For an average of 12.50 months, 42.31% had no symptoms, while others had residual (19.23%), other metastasis (15.38%), and pain (7.69%). On follow-up of 29 patients, most (68.97%) had resolved symptoms; 61.97% of the 71 patients followed were alive. |
