| Autor: |
Park SM; Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea.; Central Research Center, Okchundang Inc., Daegu 41059, Republic of Korea., Jung CJ; Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea.; Central Research Center, Okchundang Inc., Daegu 41059, Republic of Korea., Lee DG; Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea.; Central Research Center, Okchundang Inc., Daegu 41059, Republic of Korea., Yu YE; Central Research Center, Okchundang Inc., Daegu 41059, Republic of Korea., Ku TH; Okchundang Korean Medicine Clinic, Ulsan 44900, Republic of Korea., Hong MS; Rodam Korean Medical Clinic, Seoul 06038, Republic of Korea., Lim TK; Rodam Korean Medical Clinic, Seoul 06038, Republic of Korea., Paeng KI; Rodam Korean Medical Clinic, Seoul 06038, Republic of Korea., Cho HK; Rodam Korean Medical Clinic, Seoul 06038, Republic of Korea., Cho IJ; Central Research Center, Okchundang Inc., Daegu 41059, Republic of Korea., Ku SK; Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea. |
| Abstrakt: |
Photoaging refers to the accumulation of skin damage which includes wrinkle formation, loss of elasticity, and epidermal thickening due to repeated ultraviolet (UV) irradiation. The present study investigated the protective effects of Elaeagnus umbellata fruit extract (Elaea) on UV-mediated photoaged skin of SKH1 hairless mice and compared the effects of Elaea with ascorbic acid. Although there was no difference in body weight between groups during experimental period, oral administration of 50-200 mg/kg Elaea once daily for 15 weeks significantly prevented an increase in skin weight, epithelial thickening of epidermis, and apoptosis caused by UV irradiation. Skin replica and histopathological analyses revealed that Elaea dose-dependently decreased wrinkle and microfold formation. In addition, Elaea administration restored UV-mediated reduction in type I collagen and hyaluronan through the inhibition of matrix metalloproteinases and p38 mitogen-activated protein kinase expression. Moreover, Elaea suppressed UV-dependent increases in superoxide anion production, fatty acid oxidation, and protein nitration by up-regulating antioxidant system. Furthermore, Elaea alleviated infiltration of inflammatory cells in UV-irradiated skin. The preventive effects of 100 mg/kg Elaea administration against UV-induced photoaging were similar to those by 100 mg/kg ascorbic acid. Collectively, the present study suggests that the E. umbellata fruit is a promising edible candidate to prevent skin photoaging. |
