Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories.

Autor: Sias AC; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Jafar Y; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Goodpaster CM; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Ramírez-Armenta K; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Wrenn TM; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Griffin NK; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Patel K; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Lamparelli AC; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Sharpe MJ; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, USA.; Integrative Center for Addictive Disorders, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychology, University of Sydney, Sydney, New South Wales, Australia., Wassum KM; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. kwassum@ucla.edu.; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. kwassum@ucla.edu.; Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, USA. kwassum@ucla.edu.; Integrative Center for Addictive Disorders, University of California, Los Angeles, Los Angeles, CA, USA. kwassum@ucla.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Apr; Vol. 27 (4), pp. 728-736. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1038/s41593-024-01586-7
Abstrakt: To make adaptive decisions, we build an internal model of the associative relationships in an environment and use it to make predictions and inferences about specific available outcomes. Detailed, identity-specific cue-reward memories are a core feature of such cognitive maps. Here we used fiber photometry, cell-type and pathway-specific optogenetic manipulation, Pavlovian cue-reward conditioning and decision-making tests in male and female rats, to reveal that ventral tegmental area dopamine (VTA DA ) projections to the basolateral amygdala (BLA) drive the encoding of identity-specific cue-reward memories. Dopamine is released in the BLA during cue-reward pairing; VTA DA →BLA activity is necessary and sufficient to link the identifying features of a reward to a predictive cue but does not assign general incentive properties to the cue or mediate reinforcement. These data reveal a dopaminergic pathway for the learning that supports adaptive decision-making and help explain how VTA DA neurons achieve their emerging multifaceted role in learning.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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