Identification and characterisation of Gamma-herpesviruses in zoo artiodactyla.

Autor: Bianchessi L; Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900, Milan, Italy., Flach E; Wildlife Health Services, Zoological Society of London (retired), Regents Park, NW1 4RY, London, UK., Monacchia G; CIRM Italian Malaria Network, University of Perugia, Perugia, Italy., Dagleish M; Division of Veterinary Pathology, Public Health and Disease Investigation, School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, 464 Bearsden Road, G61 1QH, Glasgow, UK., Maley M; Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 OPZ, Penicuik, UK., Turin L; Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900, Milan, Italy. lauretta.turin@unimi.it., Rocchi MS; Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 OPZ, Penicuik, UK.
Jazyk: angličtina
Zdroj: Virology journal [Virol J] 2024 Feb 23; Vol. 21 (1), pp. 49. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1186/s12985-024-02311-3
Abstrakt: Background: Viruses within the γ-herpesviruses subfamily include the causative agents of Malignant Catarrhal Fever (MCF) in several species of the order Artiodactyla. MCF is a usually fatal lymphoproliferative disease affecting non-adapted host species. In adapted host species these viruses become latent and recrudesce and transmit during times of stress or immunosuppression. The undetected presence of MCF-causing viruses (MCFVs) is a risk to non-adapted hosts, especially within non-sympatric zoological collections. This study investigated the presence of MCFVs in six different zoological collections in the UK, to evaluate the presence of subclinical/latent MCFVs in carrier animals.
Methods: One-hundred and thirty eight samples belonging to 54 different species of Artiodactyla were tested by Consensus Pan-herpes PCR. The positive samples were sequenced and subjected to phylogenetic analyses to understand their own evolutionary relationships and those with their hosts.
Results: Twenty-five samples from 18 different species tested positive. All viruses but one clustered in the γ-herpesvirus family and within the Macavirus as well as the non-Macavirus groups (caprinae and alcelaphinae/hippotraginae clusters, respectively). A strong association between virus and host species was evident in the Macavirus group and clustering within the caprinae group indicated potential pathogenicity.
Conclusion: This study shows the presence of pathogenic and non-pathogenic MCFVs, as well as other γ-herpesviruses, in Artiodactyla species of conservation importance and allowed the identification of new herpesviruses in some non-adapted species.
(© 2024. The Author(s).)
Databáze: MEDLINE
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