| Autor: |
Her TK; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Li J; Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.; Institute of Neuroscience and Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal University, Zhoukou 466001, China., Lin H; Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA., Liu D; Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.; Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA 94304, USA., Root KM; Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA., Regal JF; Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA., Alejandro EU; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Cao R; Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.; Department of Neurology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA. |
| Abstrakt: |
Circadian rhythm disruption is associated with impaired glucose homeostasis and type 2 diabetes. For example, night shift work is associated with an increased risk of gestational diabetes. However, the effects of chronic circadian disruption since early life on adult metabolic health trajectory remain unknown. Here, using the "Short Day" (SD) mouse model, in which an 8 h/8 h light/dark (LD) cycle was used to disrupt mouse circadian rhythms across the lifespan, we investigated glucose homeostasis in adult mice. Adult SD mice were fully entrained into the 8 h/8 h LD cycle, and control mice were entrained into the 12 h/12 h LD cycle. Under a normal chow diet, female and male SD mice displayed a normal body weight trajectory. However, female but not male SD mice under a normal chow diet displayed glucose intolerance and insulin resistance, which are associated with impaired insulin signaling/AKT in the skeletal muscle and liver. Under high-fat diet (HFD) challenges, male but not female SD mice demonstrated increased body weight gain compared to controls. Both male and female SD mice developed glucose intolerance under HFD. Taken together, these results demonstrate that environmental disruption of circadian rhythms contributes to obesity in a sexually dimorphic manner but increases the risk of glucose intolerance and insulin resistance in both males and females. |
