Genetic Variability of Bovine Leukemia Virus: Evidence of Dual Infection, Recombination and Quasi-Species.
| Autor: | Pluta A; Department of Biochemistry, National Veterinary Research Institute, 24-100 Puławy, Poland., Rola-Łuszczak M; Department of Biochemistry, National Veterinary Research Institute, 24-100 Puławy, Poland., Hoffmann FG; Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Starkville, MS 39762, USA.; Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Starkville, MS 39762, USA., Donnik I; Ural State Agrarian University, Ekaterinburg 620075, Russia., Petropavlovskiy M; Ural Federal Agrarian Scientific Research Centre of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620049, Russia., Kuźmak J; Department of Biochemistry, National Veterinary Research Institute, 24-100 Puławy, Poland. |
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| Jazyk: | angličtina |
| Zdroj: | Pathogens (Basel, Switzerland) [Pathogens] 2024 Feb 15; Vol. 13 (2). Date of Electronic Publication: 2024 Feb 15. |
| DOI: | 10.3390/pathogens13020178 |
| Abstrakt: | We have characterized the intrahost genetic variation in the bovine leukemia virus (BLV) by examining 16 BLV isolates originating from the Western Siberia-Tyumen and South Ural-Chelyabinsk regions of Russia. Our research focused on determining the genetic composition of an 804 bp fragment of the BLV env gene, encoding for the entire gp51 protein. The results provide the first indication of the quasi-species genetic nature of BLV infection and its relevance for genome-level variation. Furthermore, this is the first phylogenetic evidence for the existence of a dual infection with BLV strains belonging to different genotypes within the same host: G4 and G7. We identified eight cases of recombination between these two BLV genotypes. The detection of quasi-species with cases of dual infection and recombination indicated a higher potential of BLV for genetic variability at the intra-host level than was previously considered. |
| Databáze: | MEDLINE |
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