Oncocytic carcinoma of the thyroid: Conclusions from a 20-year patient cohort.

Autor: Gruszczynski NR; Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA., Hasan SS; School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Brennan AG; School of Medicine, University of Virginia, Charlottesville, Virginia, USA., De La Chapa J; Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA., Reddy AS; Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA., Martin DN; School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Batchala PP; Department of Radiology and Medicine Imaging, University of Virginia, Charlottesville, Virginia, USA., Stelow EB; Department of Pathology, University of Virginia, Charlottesville, Virginia, USA., Dowling EM; Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA., Fedder KL; Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA., Garneau JC; School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Shonka DC Jr; Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2024 Aug; Vol. 46 (8), pp. 2042-2047. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1002/hed.27700
Abstrakt: Background: Oncocytic carcinoma (OCA) was recently reclassified as a distinct differentiated thyroid carcinoma (DTC). Given its rarity, OCA studies are limited. This study describes the characteristics of OCA in a 20-year cohort.
Methods: Retrospective analysis of patients with OCA at a single tertiary care hospital from 2000 to 2021.
Results: Fifty-one OCA patients (22M:29F) were identified. The mean age at diagnosis was 60.3 years; 90% presented as palpable mass; 24% had a family history of thyroid cancer. None had vocal fold paresis. On ultrasound, most tumors were solid and hypoechoic. FNA (n = 14) showed Bethesda-4 lesions in 93%. All were treated surgically. Histologically, 63% demonstrated angioinvasion, 35% had lymphovascular invasion, and 15% had extrathyroidal extension. Radioactive iodine was used as adjunct therapy in 77%.
Conclusion: OCA has distinct features that distinguish it from other DTCs, and additional focused studies will help clarify the aggressive nature, treatment options, and prognosis of the disease.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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