Determination of Aminophylline in Human Serum Using Hydrogel Microspheres for Coupled Surface-Enhanced Raman Spectroscopy (SERS) and Solid-Phase Extraction.
| Autor: | Wang Y; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China., Kong H; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China., Chen R; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China., Xu Z; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China., Zhou P; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China., Zhan Y; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China., Huang W; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China.; Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi, China., Cheng H; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China.; Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi, China., Li L; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China.; Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi, China., Feng J; Guangxi Key Laboratory of Green Processing of Sugar Resources, Faculty of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City, Guangxi, China. |
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| Jazyk: | angličtina |
| Zdroj: | Applied spectroscopy [Appl Spectrosc] 2024 May; Vol. 78 (5), pp. 551-560. Date of Electronic Publication: 2024 Feb 22. |
| DOI: | 10.1177/00037028241233016 |
| Abstrakt: | Aminophylline (AMP) is a bronchodilator. The therapeutic and toxic doses are very close. Therefore, therapeutic drug monitoring (TDM) of AMP is essential in clinical practice. Microgels were synthesized by free radical precipitation polymerization. Silver@poly( N -isopropyl acrylamide) (Ag@PNIPAM) hybrid microgels were obtained by loading silver (Ag) nanoparticles into the three-dimensional network of the microgels by in situ reduction. The microgel is a three-dimensional reticular structure with tunable pore size, large specific surface area, and good biocompatibility, which can be used as a sorbent for solid-phase extraction (SPE) of target molecules in complex matrices and as a surface-enhanced Raman spectroscopy (SERS) substrate. We optimized the conditions affecting SERS enhancement, such as silver nitrate (AgNO Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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