Oral mucous membrane pemphigoid: updates in diagnosis and management.

Autor: Kulkarni R; Assistant Professor of Oral Medicine, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA., T Stoopler E; Professor of Oral Medicine, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA., P Sollecito T; Professor and Chair of Oral Medicine, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA. tps@upenn.edu.
Jazyk: angličtina
Zdroj: British dental journal [Br Dent J] 2024 Feb; Vol. 236 (4), pp. 293-296. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1038/s41415-024-7064-x
Abstrakt: Mucous membrane pemphigoid (MMP) is a rare, immune-mediated, vesiculobullous disease that predominantly affects the oral cavity and conjunctiva. In MMP, autoantibodies are directed against hemidesmosomal proteins in the basement membrane zone, most commonly BP180. Clinical signs and symptoms include gingival desquamation, erosions, and ulcerations. Differential diagnoses include other immune-mediated blistering diseases, such as bullous pemphigoid. Definitive diagnosis is reached through history taking, physical examination, tissue biopsy and/or serology testing. MMP, although not curable, is typically managed with topical or systemic corticosteroids, in addition to immunosuppressive therapies and biologic agents in recalcitrant cases. Untreated MMP can lead to life-threatening complications, such as blindness. As a condition that affects the oral cavity, it is important that dentists understand how to recognise, diagnose and manage the disease.
(© 2024. The Author(s), under exclusive licence to the British Dental Association.)
Databáze: MEDLINE
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