The neuroprotective potential of curcumin on T. Spiralis infected mice.
| Autor: | Abdeltawab MS; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdel-Shafi IR; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt., Aboulhoda BE; Anatomy and Embryology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Mahfoz AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt. amal.mahfoz@pharm.mti.edu.eg., Hamed AM; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2024 Feb 22; Vol. 24 (1), pp. 99. Date of Electronic Publication: 2024 Feb 22. |
| DOI: | 10.1186/s12906-024-04399-0 |
| Abstrakt: | Background: Trichinella spiralis can affect the brain by inducing inflammatory and vascular changes. Drug management with the antiparasitic drug albendazole can be enhanced by natural compounds such as curcumin. The potential benefit of curcumin as an adjuvant to albendazole in the management of cerebral affection during experimental T. spiralis infection was evaluated. Animals received either curcumin 150 mg/Kg, albendazole 50 mg/Kg or a combination of both drugs. Animal groups receiving treatment were compared with infected and non-infected control groups. Blood levels of reduced glutathione (GSH) and dopamine were measured, and brain tissue expression of cyclooxygenase-2 enzyme (COX-2) and CD34 was assessed by immunohistochemistry. Results: T. spiralis infection resulted in a state of oxidative stress, which was improved by albendazole and curcumin. Also, both drugs restored the peripheral dopamine level, which was decreased in infected non-treated mice. Curcumin was also found to be efficient in improving brain pathology and reducing local COX-2 and CD 34 expression. Conclusions: Inflammatory and pathological changes during neurotrichinosis can be improved by the addition of curcumin to conventional anti-parasitic drugs. (© 2024. The Author(s).) |
| Databáze: | MEDLINE |
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