Neural circuits for the adaptive regulation of fear and extinction memory.

Autor:	Plas SL; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.; Institute for Neuroscience, Texas A&M University, College Station, TX, United States., Tuna T; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.; Institute for Neuroscience, Texas A&M University, College Station, TX, United States., Bayer H; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.; Institute for Neuroscience, Texas A&M University, College Station, TX, United States., Juliano VAL; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Sweck SO; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.; Institute for Neuroscience, Texas A&M University, College Station, TX, United States., Arellano Perez AD; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States., Hassell JE; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States., Maren S; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.; Institute for Neuroscience, Texas A&M University, College Station, TX, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in behavioral neuroscience [Front Behav Neurosci] 2024 Feb 02; Vol. 18, pp. 1352797. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).
DOI:	10.3389/fnbeh.2024.1352797
Abstrakt:	The regulation of fear memories is critical for adaptive behaviors and dysregulation of these processes is implicated in trauma- and stress-related disorders. Treatments for these disorders include pharmacological interventions as well as exposure-based therapies, which rely upon extinction learning. Considerable attention has been directed toward elucidating the neural mechanisms underlying fear and extinction learning. In this review, we will discuss historic discoveries and emerging evidence on the neural mechanisms of the adaptive regulation of fear and extinction memories. We will focus on neural circuits regulating the acquisition and extinction of Pavlovian fear conditioning in rodent models, particularly the role of the medial prefrontal cortex and hippocampus in the contextual control of extinguished fear memories. We will also consider new work revealing an important role for the thalamic nucleus reuniens in the modulation of prefrontal-hippocampal interactions in extinction learning and memory. Finally, we will explore the effects of stress on this circuit and the clinical implications of these findings. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Plas, Tuna, Bayer, Juliano, Sweck, Arellano Perez, Hassell and Maren.)
Databáze:	MEDLINE
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